Durability of ChAdOx1 nCoV-19 vaccination in people living with HIV

被引：37

作者：

Ogbe, Ane ^{[1
]}

Pace, Matthew ^{[1
]}

Bittaye, Mustapha ^{[2
]}

Tipoe, Timothy ^{[1
]}

Adele, Sandra ^{[1
]}

Alagaratnam, Jasmini ^{[3
,4
]}

Aley, Parvinder K. ^{[5
]}

Ansari, M. Azim ^{[1
]}

Bara, Anna ^{[6
,7
]}

Broadhead, Samantha ^{[8
]}

Brown, Anthony ^{[1
]}

Brown, Helen ^{[1
]}

Cappuccini, Federica ^{[2
]}

Cinardo, Paola ^{[9
,10
]}

Dejnirattisai, Wanwisa ^{[11
]}

Ewer, Katie J. ^{[2
]}

Fok, Henry ^{[9
,10
]}

Folegatti, Pedro M. ^{[2
]}

Fowler, Jamie ^{[2
]}

Godfrey, Leila ^{[2
]}

Goodman, Anna L. ^{[9
,10
]}

Jackson, Bethany ^{[9
,10
]}

Jenkin, Daniel ^{[2
]}

Jones, Mathew ^{[1
]}

Longet, Stephanie ^{[11
]}

Makinson, Rebecca A. ^{[2
]}

Marchevsky, Natalie G. ^{[5
]}

Mathew, Moncy ^{[9
,10
]}

Mazzella, Andrea ^{[9
,10
]}

Mujadidi, Yama F. ^{[5
]}

Parolini, Lucia ^{[1
]}

Petersen, Claire ^{[3
,4
]}

Plested, Emma ^{[5
]}

Pollock, Katrina M. ^{[6
,7
]}

Rajeswaran, Thurkka ^{[9
,10
]}

Ramasamy, Maheshi N. ^{[5
]}

Rhead, Sarah ^{[5
]}

Robinson, Hannah ^{[5
]}

Robinson, Nicola ^{[1
,12
]}

Sanders, Helen ^{[2
]}

Serrano, Sonia ^{[8
]}

Tipton, Tom ^{[11
]}

Waters, Anele ^{[9
,10
]}

Zacharopoulou, Panagiota ^{[1
]}

Barnes, Eleanor ^{[1
,2
,12
,13
]}

Dunachie, Susanna ^{[1
,13
,14
,15
]}

Goulder, Philip ^{[1
,13
,16
]}

Klenerman, Paul ^{[1
,12
,13
]}

Screaton, Gavin R. ^{[11
]}

Winston, Alan ^{[3
,4
]}

机构：

[1] Univ Oxford, Nuffield Dept Clin Med, Peter Medawar Bldg Pathogen Res, Oxford OX1 3SY, England

[2] Univ Oxford, Nuffield Dept Med, Jenner Inst, Oxford, England

[3] Imperial Coll London, Fac Med, Dept Infect Dis, London, England

[4] Imperial Coll Healthcare NHS Trust, St Marys Hosp, Dept HIV Med, London, England

[5] Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford, England

[6] NIHR Imperial Clin Res Facil, London, England

[7] NIHR Imperial Biomed Res Ctr, London, England

[8] NIHR Guys & St Thomas Biomed Res Ctr, London, England

[9] Guys & St Thomas NHS Trust, Dept Infect, Harrison Wing, London, England

[10] Guys & St Thomas NHS Trust, NIHR Clin Res Facil, London, England

[11] Univ Oxford, Nuffield Dept Med, Wellcome Ctr Human Genet, Oxford, England

[12] NIHR Oxford Biomed Res Ctr, Oxford, England

[13] Oxford Univ Hosp NHS Fdn Trust, Oxford, England

[14] Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England

[15] Mahidol Univ, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand

[16] Univ Oxford, Dept Paediat, Oxford, England

[17] Publ Hlth England, Porton Down, England

来源：

JCI INSIGHT | 2022年 / 7卷 / 07期

基金：

英国科研创新办公室; 英国惠康基金; 英国工程与自然科学研究理事会;

关键词：

SARS-COV-2; INFECTION; IMMUNE ACTIVATION; ANTIRETROVIRAL THERAPY; INFLUENZA; CELL; ANTIBODIES; INDIVIDUALS; VACCINES; IMMUNOGENICITY; CHEMOKINE;

D O I：

10.1172/jci.insight.157031

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Duration of protection from SARS-CoV-2 infection in people living with HIV (PWH) following vaccination is unclear. In a substudy of the phase II/III the COV002 trial (NCT04400838), 54 HIV+ male participants on antiretroviral therapy (undetectable viral loads, CD4(+) T cells > 350 cells/mu L) received 2 doses of ChAdOx1 nCoV-19 (AZD1222) 4-6 weeks apart and were followed for 6 months. Responses to vaccination were determined by serology (IgG ELISA and Meso Scale Discovery [MSD]), neutralization, ACE-2 inhibition, IFN-gamma ELISpot, activation-induced marker (AIM) assay and T cell proliferation. We show that, 6 months after vaccination, the majority of measurable immune responses were greater than prevaccination baseline but with evidence of a decline in both humoral and cell-mediated immunity. There was, however, no significant difference compared with a cohort of HIV-uninfected individuals vaccinated with the same regimen. Responses to the variants of concern were detectable, although they were lower than WT. Preexisting cross-reactive T cell responses to SARS-CoV-2 spike were associated with greater postvaccine immunity and correlated with prior exposure to beta coronaviruses. These data support the ongoing policy to vaccinate PWH against SARS-CoV-2, and they underpin the need for long-term monitoring of responses after vaccination.

引用

页数：19

共 68 条

[21] Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial [J].

Folegatti, Pedro M. ;

Ewer, Katie J. ;

Aley, Parvinder K. ;

Angus, Brian ;

Becker, Stephan ;

Belij-Rammerstorfer, Sandra ;

Bellamy, Duncan ;

Bibi, Sagida ;

Bittaye, Mustapha ;

Clutterbuck, Elizabeth A. ;

Dold, Christina ;

Faust, Saul N. ;

Finn, Adam ;

Flaxman, Amy L. ;

Hallis, Bassam ;

Heath, Paul ;

Jenkin, Daniel ;

Lazarus, Rajeka ;

Makinson, Rebecca ;

Minassian, Angela M. ;

Pollock, Katrina M. ;

Ramasamy, Maheshi ;

Robinson, Hannah ;

Snape, Matthew ;

Tarrant, Richard ;

Voysey, Merryn ;

Green, Catherine ;

Douglas, Alexander D. ;

Hill, Adrian V. S. ;

Lambe, Teresa ;

Gilbert, Sarah C. ;

Pollard, Andrew J. .

LANCET, 2020, 396 (10249) :467-478

[22] Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in HIV infection: a single-arm substudy of a phase 2/3 clinical trial [J].

Frater, John ;

Ewer, Katie J. ;

Ogbe, Ane ;

Pace, Mathew ;

Adele, Sandra ;

Adland, Emily ;

Alagaratnam, Jasmini ;

Aley, Parvinder K. ;

Ali, Mohammad ;

Ansari, M. Azim ;

Bara, Anna ;

Bittaye, Mustapha ;

Broadhead, Samantha ;

Brown, Anthony ;

Brown, Helen ;

Cappuccini, Federica ;

Cooney, Enya ;

Dejnirattisai, Wanwisa ;

Dold, Christina ;

Fairhead, Cassandra ;

Fok, Henry ;

Folegatti, Pedro M. ;

Fowler, Jamie ;

Gibbs, Charlotte ;

Goodman, Anna L. ;

Jenkin, Daniel ;

Jones, Mathew ;

Makinson, Rebecca ;

Marchevsky, Natalie G. ;

Mujadidi, Yama F. ;

Nguyen, Hanna ;

Parolini, Lucia ;

Petersen, Claire ;

Plested, Emma ;

Pollock, Katrina M. ;

Ramasamy, Maheshi N. ;

Rhead, Sarah ;

Robinson, Hannah ;

Robinson, Nicola ;

Rongkard, Patpong ;

Ryan, Fiona ;

Serrano, Sonia ;

Tipoe, Timothy ;

Voysey, Merryn ;

Waters, Anele ;

Zacharopoulou, Panagiota ;

Barnes, Eleanor ;

Dunachie, Susanna ;

Goulder, Philip ;

Klenerman, Paul .

LANCET HIV, 2021, 8 (08) :E474-E485

[23] SARS-CoV-2 variants of concern partially escape humoral but not T- cell responses in COVID-19 convalescent donors and vaccinees [J].

Geers, Daryl ;

Shamier, Marc C. ;

Bogers, Susanne ;

den Hartog, Gerco ;

Gommers, Lennert ;

Nieuwkoop, Nella N. ;

Schmitz, Katharina S. ;

Rijsbergen, Laurine C. ;

van Osch, Jolieke A. T. ;

Dijkhuizen, Emma ;

Smits, Gaby ;

Comvalius, Anouskha ;

van Mourik, Djenolan ;

Caniels, Tom G. ;

van Gils, Marit J. ;

Sanders, Rogier W. ;

Munnink, Bas B. Oude ;

Molenkamp, Richard ;

de Jager, Herbert J. ;

Haagmans, Bart L. ;

de Swart, Rik L. ;

Koopmans, Marion P. G. ;

van Binnendijk, Robert S. ;

de Vries, Rory D. ;

GeurtsvanKessel, Corine H. .

SCIENCE IMMUNOLOGY, 2021, 6 (59)

[24] Outcomes of Coronavirus Disease 2019 (COVID-19) Related Hospitalization Among People With Human Immunodeficiency Virus (HIV) in the ISARIC World Health Organization (WHO) Clinical Characterization Protocol (UK): A Prospective Observational Study [J].

Geretti, Anna Maria ;

Stockdale, Alexander J. ;

Kelly, Sophie H. ;

Cevik, Muge ;

Collins, Simon ;

Waters, Laura ;

Villa, Giovanni ;

Docherty, Annemarie ;

Harrison, Ewen M. ;

Turtle, Lance ;

Openshaw, Peter J. M. ;

Baillie, J. Kenneth ;

Sabin, Caroline A. ;

Semple, Malcolm G. .

CLINICAL INFECTIOUS DISEASES, 2021, 73 (07) :E2095-E2105

[25] VACCINE STRATEGIES - TARGETING HELPER T-CELL RESPONSES [J].

GOLDING, B ;

SCOTT, DE .

COMBINED VACCINES AND SIMULTANEOUS ADMINISTRATION: CURRENT ISSUES AND PERSPECTIVES, 1995, 754 :126-137

[26] Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals [J].

Grifoni, Alba ;

Weiskopf, Daniela ;

Ramirez, Sydney, I ;

Mateus, Jose ;

Dan, Jennifer M. ;

Moderbacher, Carolyn Rydyznski ;

Rawlings, Stephen A. ;

Sutherland, Aaron ;

Premkumar, Lakshmanane ;

Jadi, Ramesh S. ;

Marrama, Daniel ;

de Silva, Aravinda M. ;

Frazier, April ;

Carlin, Aaron F. ;

Greenbaum, Jason A. ;

Peters, Bjoern ;

Krammer, Florian ;

Smith, Davey M. ;

Crotty, Shane ;

Sette, Alessandro .

CELL, 2020, 181 (07) :1489-+

[27] Inflammation, Immune Activation, and Antiretroviral Therapy in HIV [J].

Hileman, Corrilynn O. ;

Funderburg, Nicholas T. .

CURRENT HIV/AIDS REPORTS, 2017, 14 (03) :93-100

[28] Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine [J].

Imai, T ;

Nagira, M ;

Takagi, S ;

Kakizaki, M ;

Nishimura, M ;

Wang, JB ;

Gray, PW ;

Matsushima, K ;

Yoshie, O .

INTERNATIONAL IMMUNOLOGY, 1999, 11 (01) :81-88

[29] Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19 [J].

Juno, Jennifer A. ;

Tan, Hyon-Xhi ;

Lee, Wen Shi ;

Reynaldi, Arnold ;

Kelly, Hannah G. ;

Wragg, Kathleen ;

Esterbauer, Robyn ;

Kent, Helen E. ;

Batten, C. Jane ;

Mordant, Francesca L. ;

Gherardin, Nicholas A. ;

Pymm, Phillip ;

Dietrich, Melanie H. ;

Scott, Nichollas E. ;

Tham, Wai-Hong ;

Godfrey, Dale, I ;

Subbarao, Kanta ;

Davenport, Miles P. ;

Kent, Stephen J. ;

Wheatley, Adam K. .

NATURE MEDICINE, 2020, 26 (09) :1428-1434

[30] Distinct Chemokine Receptor Axes Regulate Th9 Cell Trafficking to Allergic and Autoimmune Inflammatory Sites [J].

Kara, Ervin E. ;

Comerford, Iain ;

Bastow, Cameron R. ;

Fenix, Kevin A. ;

Litchfield, Wendel ;

Handel, Tracy M. ;

McColl, Shaun R. .

JOURNAL OF IMMUNOLOGY, 2013, 191 (03) :1110-1117

← 1 2 3 4 5 6 7 →