Durability of ChAdOx1 nCoV-19 vaccination in people living with HIV

被引：37

作者：

Ogbe, Ane ^{[1
]}

Pace, Matthew ^{[1
]}

Bittaye, Mustapha ^{[2
]}

Tipoe, Timothy ^{[1
]}

Adele, Sandra ^{[1
]}

Alagaratnam, Jasmini ^{[3
,4
]}

Aley, Parvinder K. ^{[5
]}

Ansari, M. Azim ^{[1
]}

Bara, Anna ^{[6
,7
]}

Broadhead, Samantha ^{[8
]}

Brown, Anthony ^{[1
]}

Brown, Helen ^{[1
]}

Cappuccini, Federica ^{[2
]}

Cinardo, Paola ^{[9
,10
]}

Dejnirattisai, Wanwisa ^{[11
]}

Ewer, Katie J. ^{[2
]}

Fok, Henry ^{[9
,10
]}

Folegatti, Pedro M. ^{[2
]}

Fowler, Jamie ^{[2
]}

Godfrey, Leila ^{[2
]}

Goodman, Anna L. ^{[9
,10
]}

Jackson, Bethany ^{[9
,10
]}

Jenkin, Daniel ^{[2
]}

Jones, Mathew ^{[1
]}

Longet, Stephanie ^{[11
]}

Makinson, Rebecca A. ^{[2
]}

Marchevsky, Natalie G. ^{[5
]}

Mathew, Moncy ^{[9
,10
]}

Mazzella, Andrea ^{[9
,10
]}

Mujadidi, Yama F. ^{[5
]}

Parolini, Lucia ^{[1
]}

Petersen, Claire ^{[3
,4
]}

Plested, Emma ^{[5
]}

Pollock, Katrina M. ^{[6
,7
]}

Rajeswaran, Thurkka ^{[9
,10
]}

Ramasamy, Maheshi N. ^{[5
]}

Rhead, Sarah ^{[5
]}

Robinson, Hannah ^{[5
]}

Robinson, Nicola ^{[1
,12
]}

Sanders, Helen ^{[2
]}

Serrano, Sonia ^{[8
]}

Tipton, Tom ^{[11
]}

Waters, Anele ^{[9
,10
]}

Zacharopoulou, Panagiota ^{[1
]}

Barnes, Eleanor ^{[1
,2
,12
,13
]}

Dunachie, Susanna ^{[1
,13
,14
,15
]}

Goulder, Philip ^{[1
,13
,16
]}

Klenerman, Paul ^{[1
,12
,13
]}

Screaton, Gavin R. ^{[11
]}

Winston, Alan ^{[3
,4
]}

机构：

[1] Univ Oxford, Nuffield Dept Clin Med, Peter Medawar Bldg Pathogen Res, Oxford OX1 3SY, England

[2] Univ Oxford, Nuffield Dept Med, Jenner Inst, Oxford, England

[3] Imperial Coll London, Fac Med, Dept Infect Dis, London, England

[4] Imperial Coll Healthcare NHS Trust, St Marys Hosp, Dept HIV Med, London, England

[5] Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford, England

[6] NIHR Imperial Clin Res Facil, London, England

[7] NIHR Imperial Biomed Res Ctr, London, England

[8] NIHR Guys & St Thomas Biomed Res Ctr, London, England

[9] Guys & St Thomas NHS Trust, Dept Infect, Harrison Wing, London, England

[10] Guys & St Thomas NHS Trust, NIHR Clin Res Facil, London, England

[11] Univ Oxford, Nuffield Dept Med, Wellcome Ctr Human Genet, Oxford, England

[12] NIHR Oxford Biomed Res Ctr, Oxford, England

[13] Oxford Univ Hosp NHS Fdn Trust, Oxford, England

[14] Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England

[15] Mahidol Univ, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand

[16] Univ Oxford, Dept Paediat, Oxford, England

[17] Publ Hlth England, Porton Down, England

来源：

JCI INSIGHT | 2022年 / 7卷 / 07期

基金：

英国科研创新办公室; 英国惠康基金; 英国工程与自然科学研究理事会;

关键词：

SARS-COV-2; INFECTION; IMMUNE ACTIVATION; ANTIRETROVIRAL THERAPY; INFLUENZA; CELL; ANTIBODIES; INDIVIDUALS; VACCINES; IMMUNOGENICITY; CHEMOKINE;

D O I：

10.1172/jci.insight.157031

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Duration of protection from SARS-CoV-2 infection in people living with HIV (PWH) following vaccination is unclear. In a substudy of the phase II/III the COV002 trial (NCT04400838), 54 HIV+ male participants on antiretroviral therapy (undetectable viral loads, CD4(+) T cells > 350 cells/mu L) received 2 doses of ChAdOx1 nCoV-19 (AZD1222) 4-6 weeks apart and were followed for 6 months. Responses to vaccination were determined by serology (IgG ELISA and Meso Scale Discovery [MSD]), neutralization, ACE-2 inhibition, IFN-gamma ELISpot, activation-induced marker (AIM) assay and T cell proliferation. We show that, 6 months after vaccination, the majority of measurable immune responses were greater than prevaccination baseline but with evidence of a decline in both humoral and cell-mediated immunity. There was, however, no significant difference compared with a cohort of HIV-uninfected individuals vaccinated with the same regimen. Responses to the variants of concern were detectable, although they were lower than WT. Preexisting cross-reactive T cell responses to SARS-CoV-2 spike were associated with greater postvaccine immunity and correlated with prior exposure to beta coronaviruses. These data support the ongoing policy to vaccinate PWH against SARS-CoV-2, and they underpin the need for long-term monitoring of responses after vaccination.

引用

页数：19

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