Decreased soluble interleukin-6 receptor in cerebrospinal fluid of patients with Alzheimer's disease

被引：39
作者：
Hampel, H
Sunderland, T
Kötter, HU
Schneider, C
Teipel, SJ
Padberg, F
Dukoff, R
Levy, J
Möller, HJ
机构：
[1] Univ Munich, Sch Med, Dept Psychiat, Geriatr Psychiat Branch, D-80336 Munich, Germany
[2] NIMH, NIH, Geriatr Psychiat Branch, Bethesda, MD 20892 USA
来源：
BRAIN RESEARCH | 1998年 / 780卷 / 02期
关键词：
Alzheimer's disease; cerebrospinal fluid; interleukin-6; soluble interleukin-6 receptor; family history; ELISA;
D O I：
10.1016/S0006-8993(97)01355-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The function of the cytokine interleukin-6 (IL-6) is augmented by soluble IL-6 receptors (sIL-6R). We investigated cerebrospinal fluid sIL-6R concentrations in patients with Alzheimer's disease (AD) compared to age-matched healthy subjects and individuals with at least one first degree relative with AD. We found a statistically significant decrease in sIL-6R levels in the AD group compared to controls. Complete analysis of the IL-6R complex seems crucial to better understand the impact of IL-6 in AD pathophysiology. (C) 1998 Elsevier Science B.V.
引用
收藏
页码：356 / 359
页数：4
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