Regional differences in metronidazole resistance and increasing clarithromycin resistance among Helicobacter pylori isolates from Japan

被引：92
作者：
Kato, M
Yamaoka, Y
Kim, JJ
Reddy, R
Asaka, M
Kashima, K
Osato, MS
El-Zaatari, FAK
Graham, DY
Kwon, DH
机构：
[1] Baylor Coll Med, Vet Affairs Med Ctr, Dept Med, Houston, TX 77030 USA
[2] Hokkaido Univ, Sch Med, Dept Endoscopy, Sapporo, Hokkaido 060, Japan
[3] Hokkaido Univ, Sch Med, Dept Internal Med 3, Sapporo, Hokkaido 060, Japan
[4] Kyoto Prefectural Univ Med, Dept Internal Med 3, Kyoto 602, Japan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 08期
关键词：
D O I：
10.1128/AAC.44.8.2214-2216.2000
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The patterns of antibiotic resistance in Helicobacter pylori were assessed in two different regions In Japan. Overall, prevalences of resistance to metronidazole and clarithromycin were 12.4 and 12.9%, respectively, While there was no difference in clarithromycin resistance, the prevalence of metronidazole resistance was significantly higher in Kyoto (23.8%) than in Sapporo (8.1%). From 1996 to 1999, the prevalence of metronidazole resistance did not change but the prevalence of clarithromycin resistance doubled (from 9.1 to 18.7%).
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页码：2214 / 2216
页数：3
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