Fatty acid balance regulates a-synuclein pathology

被引：1

作者：

Cohen-Adiv, Stav ^{[1
]}

Ashkenazi, Avraham ^{[1
,2
]}

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Dept Cell & Dev Biol, Tel Aviv, Israel

[2] Tel Aviv Univ, Sagol Sch Neurosci, Tel Aviv, Israel

来源：

TRENDS IN NEUROSCIENCES | 2022年 / 45卷 / 06期

关键词：

PARKINSONS-DISEASE; BINDING;

D O I：

10.1016/j.tins.2022.03.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A recent study by Tripathi et al. used a protein engineering approach to demonstrate that cellular stress caused by familial alpha-synuclein mu-tations can be alleviated by altering the monounsaturated fatty acid equilibrium in neuronal cells. This work supports the notion that meta-bolic perturbation of lipids may be involved in the pathogenesis of Parkinson's disease.

引用

页码：417 / 418

页数：2

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