Discovery of post-translational modifications in immunometabolism by chemical proteomics

被引：14

作者：

Zhang, Yanling ^{[1
,3
]}

Qin, Wei ^{[1
,3
]}

Wang, Chu ^{[1
,2
,3
]}

机构：

[1] Peking Univ, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Synthet & Funct Biomol Ctr,Beijing Natl Lab Mol S, Beijing 100871, Peoples R China

[2] Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

[3] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2021年 / 68卷

基金：

中国国家自然科学基金;

关键词：

METABOLIC-REGULATION; LYSINE MALONYLATION; FUMARATE; ITACONATE; REVEALS; PROBE; DEHYDROGENASE; SUCCINYLATION; INFLAMMATION; SUCCINATION;

D O I：

10.1016/j.copbio.2020.09.013

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolic reprogramming of macrophages during immune activation can generate diversified types of small molecule metabolites, which in turn induce post-translational modifications (PTMs) on proteins. Understanding the functional implications of these modifications requires precise identification of them from complex biological samples. We herein review recent progress in systematic discovery of immunometabolite PTMs by chemical proteomics.

引用

页码：37 / 43

页数：7

共 68 条

[11] Myristoylome Profiling Reveals a Concerted Mechanism of ARF GTPase Deacylation by the Bacterial Protease IpaJ [J].

Burnaevskiy, Nikolay ;

Peng, Tao ;

Reddick, L. Evan ;

Hang, Howard C. ;

Alto, Neal M. .

MOLECULAR CELL, 2015, 58 (01) :110-122

[12] An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation [J].

Carroll, Richard G. ;

Zaslona, Zbigniew ;

Galvan-Pena, Silvia ;

Koppe, Emma L. ;

Sevin, Daniel C. ;

Angiari, Stefano ;

Triantafilou, Martha ;

Triantafilou, Kathy ;

Modis, Louise K. ;

O'Neill, Luke A. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (15) :5509-5521

[13] The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition [J].

Chang, Pamela V. ;

Hao, Liming ;

Offermanns, Stefan ;

Medzhitov, Ruslan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (06) :2247-2252

[14] Macrophage-mediated inflammation in metabolic disease [J].

Chawla, Ajay ;

Nguyen, Khoa D. ;

Goh, Y. P. Sharon .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (11) :738-749

[15] Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe [J].

Chen, Ying ;

Liu, Yuan ;

Lan, Tong ;

Qin, Wei ;

Zhu, Yuntao ;

Qin, Ke ;

Gao, Jinjun ;

Wang, Haobo ;

Hou, Xiaomeng ;

Chen, Nan ;

Angeli, Jose Pedro Friedmann ;

Conrad, Marcus ;

Wang, Chu .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 140 (13) :4712-4720

[16] mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity [J].

Cheng, Shih-Chin ;

Quintin, Jessica ;

Cramer, Robert A. ;

Shepardson, Kelly M. ;

Saeed, Sadia ;

Kumar, Vinod ;

Giamarellos-Bourboulis, Evangelos J. ;

Martens, Joost H. A. ;

Rao, Nagesha Appukudige ;

Aghajanirefah, Ali ;

Manjeri, Ganesh R. ;

Li, Yang ;

Ifrim, Daniela C. ;

Arts, Rob J. W. ;

van der Meer, Brian M. J. W. ;

Deen, Peter M. T. ;

Logie, Colin ;

O'Neill, Luke A. ;

Willems, Peter ;

van de Veerdonk, Frank L. ;

van der Meer, Jos W. M. ;

Ng, Aylwin ;

Joosten, Leo A. B. ;

Wijmenga, Cisca ;

Stunnenberg, Hendrik G. ;

Xavier, Ramnik J. ;

Netea, Mihai G. .

SCIENCE, 2014, 345 (6204) :1579-+

[17] A mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides [J].

Chick, Joel M. ;

Kolippakkam, Deepak ;

Nusinow, David P. ;

Zhai, Bo ;

Rad, Ramin ;

Huttlin, Edward L. ;

Gygi, Steven P. .

NATURE BIOTECHNOLOGY, 2015, 33 (07) :743-749

[18] Lysine Malonylation Is Elevated in Type 2 Diabetic Mouse Models and Enriched in Metabolic Associated Proteins [J].

Du, Yipeng ;

Cai, Tanxi ;

Li, Tingting ;

Xue, Peng ;

Zhou, Bo ;

He, Xiaolong ;

Wei, Peng ;

Liu, Pingsheng ;

Yang, Fuquan ;

Wei, Taotao .

MOLECULAR & CELLULAR PROTEOMICS, 2015, 14 (01) :227-236

[19] Mitochondrial metabolites: undercover signalling molecules [J].

Frezza, Christian .

INTERFACE FOCUS, 2017, 7 (02)

[20] Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes [J].

Gaffney, Dominique O. ;

Jennings, Erin Q. ;

Anderson, Colin C. ;

Marentette, John O. ;

Shi, Taoda ;

Oxvig, Anne-Mette Schou ;

Streeter, Matthew D. ;

Johannsen, Mogens ;

Spiegel, David A. ;

Chapman, Eli ;

Roede, James R. ;

Galligan, James J. .

CELL CHEMICAL BIOLOGY, 2020, 27 (02) :206-+

← 1 2 3 4 5 6 7 →