Discovery of post-translational modifications in immunometabolism by chemical proteomics

被引：14

作者：

Zhang, Yanling ^{[1
,3
]}

Qin, Wei ^{[1
,3
]}

Wang, Chu ^{[1
,2
,3
]}

机构：

[1] Peking Univ, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Synthet & Funct Biomol Ctr,Beijing Natl Lab Mol S, Beijing 100871, Peoples R China

[2] Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

[3] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2021年 / 68卷

基金：

中国国家自然科学基金;

关键词：

METABOLIC-REGULATION; LYSINE MALONYLATION; FUMARATE; ITACONATE; REVEALS; PROBE; DEHYDROGENASE; SUCCINYLATION; INFLAMMATION; SUCCINATION;

D O I：

10.1016/j.copbio.2020.09.013

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolic reprogramming of macrophages during immune activation can generate diversified types of small molecule metabolites, which in turn induce post-translational modifications (PTMs) on proteins. Understanding the functional implications of these modifications requires precise identification of them from complex biological samples. We herein review recent progress in systematic discovery of immunometabolite PTMs by chemical proteomics.

引用

页码：37 / 43

页数：7

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