In vivo investigation of human cone photoreceptors with SLO/OCT in combination with 3D motion correction on a cellular level

被引：49

作者：

Pircher, Michael ^{[1
]}

Goetzinger, Erich ^{[1
]}

Sattmann, Harald ^{[1
]}

Leitgeb, Rainer A. ^{[1
]}

Hitzenberger, Christoph K. ^{[1
]}

机构：

[1] Med Univ Vienna, Ctr Med Phys & Biomed Engn, A-1090 Vienna, Austria

来源：

OPTICS EXPRESS | 2010年 / 18卷 / 13期

基金：

奥地利科学基金会;

关键词：

OPTICAL COHERENCE TOMOGRAPHY; LIVING HUMAN RETINA; ULTRA-HIGH-SPEED; ADAPTIVE OPTICS; HIGH-RESOLUTION; HUMAN EYE;

D O I：

10.1364/OE.18.013935

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We present a further improvement of our SLO/OCT imaging system which enables to practically eliminate all eye motion artifacts with a correction accuracy approaching sub-cellular dimensions. Axial eye tracking is achieved by using a hardware based, high speed tracking system that consists of a rapid scanning optical delay line in the reference arm of the interferometer. A software based algorithm is employed to correct for transverse eye motion in a post-processing step. The instrument operates at a frame rate of 40 en-face fps with a field of view of similar to 1 degrees x1 degrees. Dynamic focusing enables the recording of 3D volumes of the human retina with cellular resolution throughout the entire imaging depth. Several volumes are stitched together to increase the total field of view. Different features of the three dimensional structure of cone photoreceptors are investigated in detail and at different eccentricities from the fovea. (C) 2010 Optical Society of America

引用

页码：13935 / 13944

页数：10

共 32 条

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