Neurologic Manifestations of Transplant Complications

被引：30

作者：

Zivkovic, Sasa A. ^{[1
,2
]}

Abdel-Hamid, Hoda ^{[3
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

[2] VA Pittsburgh Healthcare Syst, Neurol Serv, Pittsburgh, PA 15240 USA

[3] Univ Pittsburgh, Div Pediat Neurol, Childrens Hosp Pittsburgh, Sch Med, Pittsburgh, PA 15201 USA

来源：

NEUROLOGIC CLINICS | 2010年 / 28卷 / 01期

关键词：

Posttransplant recovery; Neurotoxicity; Opportunistic infections; Transplant complications; BONE-MARROW-TRANSPLANTATION; SOLID-ORGAN TRANSPLANTATION; STEM-CELL TRANSPLANTATION; INDUCED PAIN SYNDROME; LIVER-TRANSPLANTATION; LUNG TRANSPLANTATION; CARDIAC TRANSPLANTATION; RENAL-TRANSPLANTATION; PEDIATRIC-PATIENTS; TACROLIMUS FK506;

D O I：

10.1016/j.ncl.2009.09.011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neurologic complications affect posttransplant recovery of more than 20% of transplant recipients. Etiology is usually related to surgical procedure of transplantation, primary disorders causing failure of transplanted organ, opportunistic infections, and neurotoxicity of immunosuppressive medications. Risk of opportunistic infections and immunosuppressant neurotoxicity is greatest within the first six months, but it persists along with long-term maintenance immunosuppression required to prevent graft rejection. Neurotoxicity may require alteration of immunosuppressive regimen, and prompt therapy of opportunistic infections improves outcomes.

引用

页码：235 / +

页数：18

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