Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities

被引：27
|
作者：
Kan, Toshiyuki
Kita, Yoichi
Morohashi, Yuichi
Tominari, Yusuke
Hosoda, Shinnosuke
Tomita, Taisuke
Natsugari, Hideaki
Iwatsubo, Takeshi
Fukuyama, Tohru
机构：
[1] Univ Shizuoka, Sch Pharmaceut Sci, Suruga Ku, Shizuoka 4228526, Japan
[2] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo, Japan
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 11期
关键词：
D O I：
10.1021/ol070376i
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Convenient synthesis of a variety of photoaffinity probes was accomplished by utilizing our Ns strategy and novel resin. The synthetic probes were evaluated via the labeling ability with the preseniline 1 C-terminal fragments, which was identified as a therapeutic target for Alzheimer's disease.
引用
收藏
页码：2055 / 2058
页数：4
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