Importance of patient selection when determining the significance of the CYP3A5 polymorphism in clinical trials

被引:5
作者
Foti, RS [1 ]
Fisher, MB [1 ]
机构
[1] Pfizer Inc, PGRD, Discovery Pharmacokinet Dynam & Metab, Groton, CT 06340 USA
关键词
D O I
10.1038/sj.tpj.6500286
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
[No abstract available]
引用
收藏
页码:362 / 364
页数:3
相关论文
共 14 条
[1]   Genotype-phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women [J].
Floyd, MD ;
Gervasini, G ;
Masica, AL ;
Mayo, G ;
George, AL ;
Bhat, K ;
Kim, RB ;
Wilkinson, GR .
PHARMACOGENETICS, 2003, 13 (10) :595-606
[2]   CYP3A5 genotype did not impact on nifedipine disposition in healthy volunteers [J].
Fukuda T. ;
Onishi S. ;
Fukuen S. ;
Ikenaga Y. ;
Ohno M. ;
Ohno M. ;
Hoshino K. ;
Matsumoto K. ;
Maihara A. ;
Momiyama K. ;
Ito T. ;
Fujio Y. ;
Azuma J. .
The Pharmacogenomics Journal, 2004, 4 (1) :34-39
[3]   Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus [J].
Hesselink, DA ;
van Schaik, RHN ;
van der Heiden, IP ;
van der Werf, M ;
Gregoor, PJHS ;
Lindemans, J ;
Weimar, W ;
van Gelder, T .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2003, 74 (03) :245-254
[4]  
Johnson Lynt B, 2004, N C Med J, V65, P35
[5]   End-stage renal disease in African-American and white men - 16-year MRFIT findings [J].
Klag, MJ ;
Whelton, PK ;
Randall, BL ;
Neaton, JD ;
Brancati, FL ;
Stamler, J .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (16) :1293-1298
[6]   Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression [J].
Kuehl, P ;
Zhang, J ;
Lin, Y ;
Lamba, J ;
Assem, M ;
Schuetz, J ;
Watkins, PB ;
Daly, A ;
Wrighton, SA ;
Hall, SD ;
Maurel, P ;
Relling, M ;
Brimer, C ;
Yasuda, K ;
Venkataramanan, R ;
Strom, S ;
Thummel, K ;
Boguski, MS ;
Schuetz, E .
NATURE GENETICS, 2001, 27 (04) :383-391
[7]   Common allelic variants of cytochrome P4503A4 and their prevalence in different populations [J].
Lamba, JK ;
Lin, YS ;
Thummel, K ;
Daly, A ;
Watkins, PB ;
Strom, S ;
Zhang, J ;
Schuetz, EG .
PHARMACOGENETICS, 2002, 12 (02) :121-132
[8]   Racial differences in renal transplantation after immunosuppression with tacrolimus versus cyclosporine [J].
Neylan, JF .
TRANSPLANTATION, 1998, 65 (04) :515-523
[9]   Pharmacokinetics of midazolam and 1′-hydroxymidazolam in Chinese with different CYP3A5 genotypes [J].
Shih, PS ;
Huang, JD .
DRUG METABOLISM AND DISPOSITION, 2002, 30 (12) :1491-1496
[10]   Impact of cytochrome P450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients [J].
Thervet, E ;
Anglicheau, D ;
King, B ;
Schlageter, MH ;
Cassinat, B ;
Beaune, P ;
Legendre, C ;
Daly, AK .
TRANSPLANTATION, 2003, 76 (08) :1233-1235