Ca2+ handling and sensitivity in airway smooth muscle: Emerging concepts for mechanistic understanding and therapeutic targeting

被引：31
作者：
Koopmans, T. [1 ]
Anaparti, V. [2 ]
Castro-Piedras, I. [3 ]
Yarova, P. [4 ]
Irechukwu, N. [5 ]
Nelson, C. [6 ]
Perez-Zoghbi, J. [3 ]
Tan, X. [7 ]
Ward, J. P. T. [5 ]
Wright, D. B. [1 ,5 ]
机构：
[1] Univ Groningen, Dept Mol Pharmacol, Groningen, Netherlands
[2] Univ Manitoba, Dept Immunol, Winnipeg, MB, Canada
[3] Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79409 USA
[4] Cardiff Univ, Cardiff Sch Biosci, Cardiff CF10 3AX, S Glam, Wales
[5] Kings Coll London, Div Asthma Allergy & Lung Biol, London WC2R 2LS, England
[6] Nottingham Trent Univ, Sch Sci & Technol, Nottingham, England
[7] QIMR Berghofer Med Res Inst, Lung Inflammat & Infect Lab, Herston, Qld, Australia
来源：
PULMONARY PHARMACOLOGY & THERAPEUTICS | 2014年 / 29卷 / 02期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
Asthma; Airway smooth muscle; Calcium; Sensitisation; WNT; Contraction; RECEPTOR TYROSINE KINASE; INTRACELLULAR CALCIUM OSCILLATIONS; ACTIVATED T-CELLS; PHOSPHOLIPASE-C BETA; SRC FAMILY KINASES; HYDROGEN-SULFIDE; RHO-KINASE; INOSITOL 1,4,5-TRISPHOSPHATE; NUCLEAR FACTOR; INDUCED HYPERRESPONSIVENESS;
D O I：
10.1016/j.pupt.2014.05.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Free calcium ions within the cytosol serve as a key secondary messenger system for a diverse range of cellular processes. Dysregulation of cytosolic Ca2+ handling in airway smooth muscle (ASM) has been implicated in asthma, and it has been hypothesised that this leads, at least in part, to associated changes in both the architecture and function of the lung. Significant research is therefore directed towards furthering our understanding of the mechanisms which control ASM cytosolic calcium, in addition to those regulating the sensitivity of its downstream effector targets to calcium. Key aspects of the recent developments in this field were discussed at the 8th Young Investigators' Symposium on Smooth Muscle (2013, Groningen, The Netherlands), and are outlined in this review. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：108 / 120
页数：13
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