Glutaric acid induces oxidative stress in brain of young rats

被引：64

作者：

Marques, FD ^{[1
]}

Hagen, MEK ^{[1
]}

Pederzolli, CD ^{[1
]}

Sgaravatti, AM ^{[1
]}

Durigon, K ^{[1
]}

Testa, CG ^{[1
]}

Wannmacher, CMD ^{[1
]}

Wyse, ATD ^{[1
]}

Wajner, M ^{[1
]}

Dutra, CS ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Dept Bioquim, Inst Ciencias Basicas Saude, BR-90035003 Porto Alegre, RS, Brazil

来源：

BRAIN RESEARCH | 2003年 / 964卷 / 01期

关键词：

glutaric acid; oxidative stress; rat brain; glutaric acidemia type I;

D O I：

10.1016/S0006-8993(02)04118-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study investigated the effects of glutaric acid, which predominantly accumulates in glutaric acidemia type 1, on some in vitro parameters of oxidative stress in brain of young rats. We evaluated chemiluminescence, total radical-antioxidant potential (TRAP) and the activities of the antioxidant enzymes catalase, glutathione peroxidase and superoxide dismutase in brain tissue homogenates in the presence of glutaric acid at concentrations ranging from 0.05 to 2.0 mM. The acid significantly increased chemiluminescence (up to 65%) and reduced total radical-antioxidant potential (up to 28%) and glutathione peroxidase activity (up to 46%), without affecting catalase and superoxide dismutase activities. The results provide evidence that glutaric acid induces oxidative stress in vitro in rat brain. If these findings also occur in humans, it is possible that they may contribute to the neuropathology of patients affected by glutaric acidemia type 1. (C) 2002 Published by Elsevier Science B.V.

引用

页码：153 / 158

页数：6

共 25 条

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