Enantioselective Iridium-Catalyzed Allylation of Acetylenic Ketones via 2-Propanol-Mediated Reductive Coupling of Allyl Acetate: C14-C23 of Pladienolide D

被引：15

作者：

Brito, Gilmar A. ^{[1
]}

Jung, Woo-Ok ^{[1
]}

Yoo, Minjin ^{[1
]}

Krische, Michael J. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Chem, 105 & 24th St,A5300, Austin, TX 78712 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 52期

基金：

巴西圣保罗研究基金会;

关键词：

enantioselectivity; iridium; ketone allylation; transfer hydrogenation; pi-allyl; C BOND FORMATION; CHIRAL TERTIARY ALCOHOLS; REVERSE PRENYLATION; ASYMMETRIC ADDITION; HOMOALLYLIC ALCOHOLS; CARBONYL-COMPOUNDS; CYCLOISOMERIZATION; PROPARGYLATION; ALLYLBORATION; HYDROGEN;

D O I：

10.1002/anie.201908939

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly enantioselective catalytic reductive coupling of allyl acetate with acetylenic ketones occurs in a chemoselective manner in the presence of aliphatic or aromatic ketones. This method was used to construct C14-C23 of pladienolide D in half the steps previously required.

引用

页码：18803 / 18807

页数：5

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