CYP7A1, BAAT and UGT1A1 polymorphisms and susceptibility to anti-tuberculosis drug-induced hepatotoxicity

被引：10

作者：

Chen, R. ^{[1
]}

Wang, J. ^{[1
]}

Tang, S-W. ^{[2
]}

Zhang, Y. ^{[3
]}

Lv, X-Z. ^{[4
,5
]}

Wu, S-S. ^{[1
]}

Yang, Z-R. ^{[1
]}

Xia, Y-Y. ^{[6
]}

Chen, D-F. ^{[1
]}

Zhan, S-Y. ^{[1
]}

机构：

[1] Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hlth Sci Ctr, 38 Xueyuan Rd, Beijing 100191, Peoples R China

[2] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China

[3] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada

[4] Peking Univ, Div Clin Res, Inst Mental Hlth, Beijing 100191, Peoples R China

[5] Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China

[6] Chinese Ctr Dis Control & Prevent, Ctr TB Control & Prevent, Beijing, Peoples R China

来源：

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2016年 / 20卷 / 06期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

ATDH; tuberculosis; pharmacogenetics; genetic susceptibility; INDUCED LIVER DISORDERS; BILE-ACID SYNTHESIS; TRANSCRIPTIONAL REGULATION; METABOLISM; INJURY; GENES;

D O I：

10.5588/ijtld.15.0450

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

SETTING: Evidence indicates that the polymorphisms in genes involved in bile acid metabolism may play an important role in the development of anti-tuberculosis drug-induced hepatotoxicity (ATDH) in tuberculosis (TB) patients treated with anti-tuberculosis drugs. OBJECTIVE: To investigate the association between genetic variants of CYP7A1, BAAT and UGT1A1 and the risk of ATDH in a Chinese cohort. DESIGN: In this nested case-control study, 89 TB patients with ATDH and 356 matched ATDH-free TB patients constituted cases and controls, respectively. Genetic polymorphisms of CYP7A1, BAAT and UGT1A1 were determined using the TaqMan single nucleotide polymorphism genotyping assay. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using a conditional logistic regression model. RESULTS: Significant differences were found in genotype distributions of rs1457043 in CYP7A1 between patients with and those without ATDH (P = 0.014). Genotype and haplotype analysis showed that patients carrying an AG genotype of rs1457043 and G-C or G-A haplotypes of rs1457043 rs8192870 in CYP7A1 were at a higher risk of ATDH than those with GG genotype and A-C haplotype, with ORs of respectively 2.05 (95 %CI 1.18-3.15) and 2.40 (95%CI 1.62-3.57). CONCLUSION: Genetic polymorphisms of CYP7A1 may be associated with susceptibility to ATDH in the Chinese population.

引用

页码：812 / 818

页数：7

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