The role of bacterial lipid diversity and membrane properties in modulating antimicrobial peptide activity and drug resistance

被引：72

作者：

Lee, Tzong-Hsien ^{[1
]}

Hofferek, Vinzenz ^{[2
]}

Separovic, Frances ^{[2
]}

Reid, Gavin E. ^{[2
,3
]}

Aguilar, Marie-Isabel ^{[1
]}

机构：

[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

[2] Univ Melbourne, Bio21 Inst, Sch Chem, Melbourne, Vic 3010, Australia

[3] Univ Melbourne, Dept Biochem & Mol Biol, Parkville, Vic 3010, Australia

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2019年 / 52卷

基金：

英国医学研究理事会;

关键词：

NM ULTRAVIOLET PHOTODISSOCIATION; OZONE-INDUCED DISSOCIATION; PATERNO-BUCHI REACTION; MASS-SPECTROMETRY; STAPHYLOCOCCUS-AUREUS; STRUCTURAL-CHARACTERIZATION; ESCHERICHIA-COLI; DOUBLE-BOND; MECHANISMS; ELUCIDATION;

D O I：

10.1016/j.cbpa.2019.05.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review provides an analysis of the role that membrane composition and structure plays in the resistance of microorganisms to antimicrobial peptides (AMPs). We describe the current models of membrane disruption caused by AMPs and the changes in the structural properties that microbial membranes undergo in response to AMPs. This is followed by an outline of how the phospholipid composition of microbial membranes contributes to the changes in membrane bilayer structure and how the composition can be analysed in significant detail by modern lipidomic techniques. Finally, we discuss the challenges to fully analyse microbial membrane composition and structure that may occur during the development of resistance to AMPs.

引用

页码：85 / 92

页数：8

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