Folic acid-functionalized tea polyphenol as a tumor-targeting nano-drug delivery system

被引：22
|
作者：
Chuan, Di [1 ,2 ,3 ]
Mu, Min [1 ,2 ,3 ]
Hou, Huan [1 ,2 ,3 ]
Zhao, Na [4 ,5 ]
Li, Jinglun [6 ]
Tong, Aiping [1 ,2 ,3 ]
Zou, Bingwen [1 ,2 ,3 ]
Chen, Haifeng [1 ,2 ,3 ]
Han, Bo [4 ,5 ]
Guo, Gang [1 ,2 ,3 ]
机构：
[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China
[3] Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Dept Neurosurg, Chengdu 610041, Peoples R China
[4] Shihezi Univ, Sch Pharm, Shihezi 832002, Peoples R China
[5] Minist Educ, Key Lab Xinjiang Phytomed Resource & Utilizat, Shihezi 832002, Peoples R China
[6] Southwest Med Univ, Affiliated Hosp, Dept Neurol, Luzhou 646000, Peoples R China
来源：
MATERIALS & DESIGN | 2021年 / 206卷
基金：
中国国家自然科学基金;
关键词：
Polyphenol; Ovarian Cancer; Folic Acid; Epigallocatechin Gallate; Nano-drug delivery system; FOLATE RECEPTOR-ALPHA; EPIGALLOCATECHIN GALLATE; CATECHIN; CANCER; NANOPARTICLES; OVARIAN; DOXORUBICIN; MICELLES;
D O I：
10.1016/j.matdes.2021.109805
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Epigallocatechin Gallate (EGCG) is the main component of green tea which can strongly bind to proteins, small molecular drugs, and DNA. Therefore, EGCG can be used to deliver biomacromolecules and drugs. In this study, a doxorubicin (DOX) delivery system (FPE/DOX NPs) based on the folic acid-functionalized EGCG was developed for the targeting therapy of ovarian cancer. Cellular uptake studies showed that FPE/DOX NPs enhanced DOX uptake by SKOV3 cells compared with PE/DOX NPs that without folic acid modification. In vitro, the toxicity of FPE/DOX NPs to SKOV3 cells was stronger than nanoparticles without folic acid modification. In vivo, the SKOV3 tumor growth inhibition effect of FPE/DOX NPs was substantially more effective than other groups. Together, the results of this study suggested that FPE/DOX NPs may have promising applications in ovarian cancer therapy. (C) 2021 The Author(s). Published by Elsevier Ltd.
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页数：9
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