Fruit and vegetable intake and the risk of overall cancer in Japanese: A pooled analysis of population-based cohort studies

被引：7

作者：

Takachi, Ribeka ^{[1
]}

Inoue, Manami ^{[2
]}

Sugawara, Yumi ^{[3
]}

Tsuji, Ichiro ^{[3
]}

Tsugane, Shoichiro ^{[4
]}

Ito, Hidemi ^{[5
]}

Matsuo, Keitaro ^{[6
]}

Tanaka, Keitaro ^{[7
]}

Tamakoshi, Akiko ^{[8
]}

Mizoue, Tetsuya ^{[9
]}

Wakai, Kenji ^{[10
]}

Nagata, Chisato ^{[11
]}

Sasazuki, Shizuka ^{[12
]}

机构：

[1] Nara Womens Univ, Gurad Sch Humanities & Sci, Dept Food Sci & Nutr, Nara, Japan

[2] Univ Tokyo, Grad Sch Med, AXA Dept Hlth & Human Secur, Tokyo, Japan

[3] Tohoku Univ, Grad Sch Med, Dept Publ Hlth & Forens Med, Div Epidemiol, Sendai, Miyagi, Japan

[4] Natl Canc Ctr, Res Ctr Canc Prevent & Screening, Tokyo, Japan

[5] Aichi Canc Ctr, Res Inst, Div Epidemiol & Prevent, Nagoya, Aichi, Japan

[6] Aichi Canc Ctr, Res Inst, Div Mol Med, Nagoya, Aichi, Japan

[7] Saga Univ, Fac Med, Saga Med Sch, Dept Prevent Med, Saga, Japan

[8] Hokkaido Univ, Grad Sch Med, Dept Publ Hlth, Sapporo, Hokkaido, Japan

[9] Natl Ctr Global Hlth & Med, Int Clin Res Ctr, Dept Epidemiol & Int Hlth, Tokyo, Japan

[10] Nagoya Univ, Grad Sch Med, Dept Prevent Med, Nagoya, Aichi, Japan

[11] Gifu Univ, Grad Sch Med, Dept Epidemiol & Prevent Med, Gifu, Japan

[12] Natl Canc Ctr, Res Ctr Canc Prevent & Screening, Prevent Div, Tokyo, Japan

来源：

JOURNAL OF EPIDEMIOLOGY | 2017年 / 27卷 / 04期

关键词：

Pooled analysis; Cancer risk; Fruit and vegetable intake; Japanese; FOOD-FREQUENCY QUESTIONNAIRE; CARDIOVASCULAR-DISEASE; BREAST-CANCER; LUNG-CANCER; ALL-CAUSE; CONSUMPTION; MORTALITY; SMOKING; TOBACCO; JPHC;

D O I：

10.1016/j.je.2016.05.004

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: A series of recent reports from large-scale cohort studies involving more than 100,000 subjects reported no or only very small inverse associations between fruit and vegetable intake and overall cancer incidence, despite having sufficient power to do so. To date, however, no such data have been reported for Asian populations. Objective: To provide some indication of the net impact of fruit and vegetable consumption on overall cancer prevention, we examined these associations in a pooled analysis of large-scale cohort studies in Japanese populations. Methods: We analyzed original data from four cohort studies that measured fruit and vegetable consumption using validated questionnaires at baseline. Hazard ratios (HRs) in the individual studies were calculated, with adjustment for a common set of variables, and combined using a random-effects model. Results: During 2,318,927 person-years of follow-up for a total of 191,519 subjects, 17,681 cases of overall cancers were identified. Consumption of fruit or vegetables was not associated with decreased risk of overall cancers: corresponding HRs for the highest versus lowest quartiles of intake for men and women were 1.03 (95% CI, 0.97-1.10; trend p = 1.00) and 1.03 (95% CI, 0.95-1.11; trend p = 0.97), respectively, for fruit and 1.07 (95% CI, 1.01-1.14; trend p = 0.18) and 0.98 (95% CI, 0.91-1.06; trend p = 0.99), respectively, for vegetables, even in analyses stratified by smoking status and alcohol drinking. Conclusions: The results of this pooled analysis do not support inverse associations of fruit and vegetable consumption with overall cancers in the Japanese population. (C) 2016 The Authors. Publishing services by Elsevier B.V. on behalf of The Japan Epidemiological Association.

引用

页码：152 / 162

页数：11