Diagnosis, treatment and supportive management of chronic lymphocytic leukemia: recommendations of the Dutch HOVON CLL working group

被引：3

作者：

Te Raa, Doreen G. ^{[1
]}

van der Straten, Lina ^{[2
,3
,4
]}

van Gelder, Michel ^{[5
]}

Kersting, Sabina ^{[6
]}

Levin, Mark-David ^{[2
]}

Mous, Rogier ^{[7
]}

van der Straaten, Hanneke M. ^{[8
]}

Nijziel, Marten R. ^{[9
]}

van der Spek, Ellen ^{[10
]}

Posthuma, Eduardus F. M. ^{[11
,12
]}

Visser, Hein P. J. ^{[13
]}

van der Klift, Marjolein ^{[14
]}

de Heer, Koen ^{[15
]}

Bellido, Mar ^{[16
]}

Doorduijn, Jeanette K. ^{[17
]}

Bruns, Anke H. W. ^{[7
]}

Raijmakers, Reinier A. P. ^{[7
]}

Kater, Arnon P. ^{[18
]}

机构：

[1] Gelderse Vallei, Dept Internal Med, Ede, Netherlands

[2] Albert Schweitzer Hosp, Dept Internal Med, Dordrecht, Netherlands

[3] Netherlands Comprehens Canc Org IKNL, Dept Res & Dev, Utrecht, Netherlands

[4] Erasmus MC, Dept Immunol, Lab Med Immunol, Rotterdam, Netherlands

[5] Maastricht UMC, Dept Hematol, Maastricht, Netherlands

[6] HAGA Hosp, Dept Internal Med, The Hague, Netherlands

[7] UMC Utrecht, Dept Hematol, Utrecht, Netherlands

[8] St Jansdal Hosp, Dept Internal Med, Harderwijk, Netherlands

[9] Catharina Hosp, Dept Internal Med, Eindhoven, Netherlands

[10] Rijnstate, Dept Internal Med, Arnhem, Netherlands

[11] Reinier de Graaf Hosp, Dept Internal Med, Delft, Netherlands

[12] Leiden Univ Med Ctr, Dept Hematol, Leiden, Netherlands

[13] Noordwest Ziekenhuisgrp, Dept Internal Med, Alkmaar, Netherlands

[14] Amphia Hosp, Dept Internal Med, Breda, Netherlands

[15] Flevo Hosp, Dept Internal Med, Almere, Netherlands

[16] Univ Groningen, Groningen Univ Med Ctr, Dept Hematol, Groningen, Netherlands

[17] Univ Med Ctr Rotterdam, Erasmus MC Canc Inst, Dept Hematol, Rotterdam, Netherlands

[18] Univ Amsterdam, Amsterdam UMC, Lymphoma & Myeloma Ctr Amsterdam, Dept Hematol,Canc Ctr Amsterdam, Amsterdam, Netherlands

来源：

LEUKEMIA & LYMPHOMA | 2022年 / 63卷 / 10期

关键词：

Chronic lymphocytic leukemia; small lymphocytic lymphoma; diagnostics; treatment; guideline; CLINICAL-PRACTICE GUIDELINES; SCORING SYSTEM; FREE SURVIVAL; OPEN-LABEL; IBRUTINIB; RITUXIMAB; CYCLOPHOSPHAMIDE; FLUDARABINE; IDELALISIB; IMPACT;

D O I：

10.1080/10428194.2022.2084731

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Management of patients with chronic lymphocytic leukemia (CLL) is changing due to considerable advances in the therapeutic armamentarium, and new therapies will possibly continue to emerge in the near future. Therefore, the CLL working group of the Dutch-Belgium Haemato-Oncology Cooperative Group for Adults in the Netherlands (HOVON) necessitated revising the Dutch CLL guidelines. The current guideline is based on the expert opinion of the HOVON CLL working group members and focusses on well-designed clinical trials taking into account efficacy with special emphasis on toxicity, treatment duration and treatment intensity. This article provides recommendations on diagnosis, treatment strategies in front-line and relapsed setting and provides supportive care measurements during novel-based therapies as well as for infectious CLL-related complications. The recommendations presented here are intended to provide guidance for the management of CLL patients in the Netherlands, and take into account the availability of treatment strategies at the time of this publication.

引用

页码：2276 / 2289

页数：14

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