Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine

被引：211
作者：
Popp, Maximilian W. [1 ,2 ]
Maquat, Lynne E. [1 ,2 ]
机构：
[1] Univ Rochester, Sch Med & Dent, Dept Biochem & Biophys, Rochester, NY 14642 USA
[2] Univ Rochester, Ctr RNA Biol, 601 Elmwood Ave, Rochester, NY 14642 USA
来源：
CELL | 2016年 / 165卷 / 06期
关键词：
IDENTIFICATION; MUTATIONS; UPF1;
D O I：
10.1016/j.cell.2016.05.053
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA quality control and regulatory process that plays direct roles in human health and disease. In this Minireview, we discuss how understanding the molecular events that trigger NMD can facilitate strategic targeting of genes via CRISPR/Cas9 technologies and also inform disease diagnostics and treatments.
引用
收藏
页码：1319 / 1322
页数：4
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