Antifungal activity of novel catecholamine ruthenium(III) complexes

被引：15

作者：

de Lima, RG

Lever, ABP

Ito, IY

da Silva, RS

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Sao Paulo, Brazil

[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Pret, Dept Quim, BR-14040901 Sao Paulo, Brazil

[3] York Univ, Dept Chem, N York, ON M3J 1P3, Canada

来源：

TRANSITION METAL CHEMISTRY | 2003年 / 28卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1023/A:1022967403627

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New catecholamine ruthenium(III) complexes with potentially interesting biological activity are described. The complexes were prepared by reacting catecholamine with [RuCl(NH3)(5)]Cl-2. The newly prepared species were formulated as [Ru-III(NH3)(4)(catecholamine-R)](n+) where catecholamine- R = noradrenaline, dopamine and isoproterenol, and were characterized by elemental analysis, e.p.r., electronic absorption and f.t.-i.r. They were moderately stable in water at room temperature for at least 1 week. In vitro tests of antifungal activity showed the ruthenium catecholamine complexes had strong inhibitory action against the pathogenic yeast Candida albicans, Candida glabrata and Candida tropicalis. Free catecholamine does not show any antifungal activity.

引用

页码：272 / 275

页数：4

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