Both atenolol and propranolol blunt the fibrinolytic response to exercise but not resting fibrinolytic potential

被引：8
作者：
Fernhall, B
Szymanski, LM
Gorman, PA
Kamimori, GH
Kessler, CM
机构：
[1] George Washington Univ, Med Ctr, Exercise Sci Programs, Washington, DC 20037 USA
[2] George Washington Univ, Med Ctr, Div Cardiol, Washington, DC 20037 USA
[3] Walter Reed Army Inst Res, Dept Neurobiol & Behav, Washington, DC USA
[4] Georgetown Univ, Med Ctr, Div Hematol Oncol, Washington, DC 20007 USA
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 2000年 / 86卷 / 12期
关键词：
D O I：
10.1016/S0002-9149(00)01242-X
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This randomized, double-blind trial found that tissue plasminogen activator activity increased and plasminogen activator inhibitor-1 activity decreased significantly more with exercise during placebo treatment than during treatment with beta blockade. These results suggest that beta blockade blunts the fibrinolytic response to maximal exercise.
引用
收藏
页码：1398 / +
页数：4
相关论文
共 19 条
[1]   THE CIRCULATORY REGULATION OF TPA AND UPA SECRETION, CLEARANCE, AND INHIBITION DURING EXERCISE AND DURING THE INFUSION OF ISOPROTERENOL AND PHENYLEPHRINE [J].
CHANDLER, WL ;
LEVY, WC ;
STRATTON, JR .
CIRCULATION, 1995, 92 (10) :2984-2994
[2]   CALCULATION OF PERCENTAGE CHANGES IN VOLUMES OF BLOOD, PLASMA, AND RED-CELLS IN DEHYDRATION [J].
DILL, DB ;
COSTILL, DL .
JOURNAL OF APPLIED PHYSIOLOGY, 1974, 37 (02) :247-248
[3]  
ELSAYED MS, 1992, MED SCI SPORT EXER, V24, P327
[4]   Fibrinolytic activity is not dependent upon exercise mode in post-myocardial infarction patients [J].
Fernhall, B ;
Szymanski, LM ;
Gorman, PA ;
Milani, J ;
Paup, DC ;
Kessler, CH .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY, 1998, 78 (03) :247-252
[5]   Fibrinolytic activity is similar in physically active men with and without a history of myocardial infarction [J].
Fernhall, B ;
Szymanski, LM ;
Gorman, PA ;
Milani, J ;
Paup, DC ;
Kessler, CM .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (06) :1106-1113
[6]  
FRIEDMAN LM, 1982, JAMA-J AM MED ASSOC, V247, P1707
[7]   EFFECT OF PROPRANOLOL, ALPRENOLOL AND PRACTOLOL ON FIBRINOLYTIC AND FACTOR-VIII RESPONSES TO ADRENALIN AND SALBUTAMOL IN MAN [J].
GADER, AMA ;
DACOSTA, J ;
CASH, JD .
THROMBOSIS RESEARCH, 1974, 4 (01) :25-33
[8]  
HAMSTEN A, 1987, LANCET, V4, P3
[9]   Fibrinolytic variables and cardiovascular prognosis in patients with stable angina pectoris treated with verapamil or metoprolol - Results from the angina prognosis study in Stockholm [J].
Held, C ;
Hjemdahl, P ;
Rehnqvist, N ;
Wallen, H ;
Bjorkander, I ;
Eriksson, SV ;
Forslund, L ;
Wiman, B .
CIRCULATION, 1997, 95 (10) :2380-2386
[10]   INCREASED OCCURRENCE OF LEFT-VENTRICULAR THROMBI DURING EARLY TREATMENT WITH TIMOLOL IN PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION [J].
JOHANNESSEN, KA ;
NORDREHAUG, JE ;
VONDERLIPPE, G .
CIRCULATION, 1987, 75 (01) :151-155
12