Drug resistance gene transfer: Stem cell protection and therapeutic efficacy

被引:14
作者
Gerson, SL
机构
[1] Case Western Reserve Univ, Div Hematol Oncol, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Ireland Canc Ctr, Cleveland, OH 44106 USA
[3] Univ Hosp Cleveland, Cleveland, OH 44106 USA
关键词
D O I
10.1016/S0301-472X(00)00548-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:1315 / 1324
页数:10
相关论文
共 32 条
[1]   Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells [J].
Abonour, R ;
Williams, DA ;
Einhorn, L ;
Hall, KM ;
Chen, J ;
Coffman, J ;
Traycoff, CM ;
Bank, A ;
Kato, I ;
Ward, M ;
Williams, SD ;
Hromas, R ;
Robertson, MJ ;
Smith, FO ;
Woo, D ;
Mills, B ;
Srour, EF ;
Cornetta, K .
NATURE MEDICINE, 2000, 6 (06) :652-658
[2]   Effects of retroviral-mediated MDR1 expression on hematopoietic stem cell self-renewal and differentiation in culture [J].
Bunting, KD ;
Galipeau, J ;
Topham, D ;
Benaim, E ;
Sorrentino, BP .
HEMATOPOIETIC STEM CELLS: BIOLOGY AND TRANSPLANTATION, 1999, 872 :125-141
[3]   Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants:: Implications for drug resistance gene therapy [J].
Davis, BM ;
Roth, JC ;
Liu, LL ;
Xu-Welliver, M ;
Pegg, AE ;
Gerson, SL .
HUMAN GENE THERAPY, 1999, 10 (17) :2769-2778
[4]  
Davis BM, 2000, BLOOD, V95, P3078
[5]   Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo [J].
Goodell, MA ;
Brose, K ;
Paradis, G ;
Conner, AS ;
Mulligan, RC .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) :1797-1806
[6]   Phase I trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation [J].
Hesdorffer, C ;
Ayello, J ;
Ward, M ;
Kaubisch, A ;
Vahdat, L ;
Balmaceda, C ;
Garrett, T ;
Fetell, M ;
Reiss, R ;
Bank, A ;
Antman, K .
JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (01) :165-172
[7]   FMEV vectors: both retroviral long terminal repeat and leader are important for high expression in transduced hematopoietic cells [J].
Hildinger, M ;
Eckert, HG ;
Schilz, AJ ;
John, J ;
Ostertag, W ;
Baum, C .
GENE THERAPY, 1998, 5 (11) :1575-1579
[8]   Design of 5′ untranslated sequences in retroviral vectors developed for medical use [J].
Hildinger, M ;
Abel, KL ;
Ostertag, W ;
Baum, C .
JOURNAL OF VIROLOGY, 1999, 73 (05) :4083-4089
[9]   Retroviral marking and transplantation of rhesus hematopoietic cells by nonmyeloablative conditioning [J].
Huhn, RD ;
Tisdale, JF ;
Agricola, B ;
Metzger, ME ;
Donahue, RE ;
Dunbar, CE .
HUMAN GENE THERAPY, 1999, 10 (11) :1783-1790
[10]  
James RI, 1997, EXP HEMATOL, V25, P1286