Brd4 is on the move during inflammation

被引：37

作者：

Xu, Yali ^{[1
,2
]}

Vakoc, Christopher R. ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[2] SUNY Stony Brook, Mol & Cellular Biol Program, Stony Brook, NY 11794 USA

来源：

TRENDS IN CELL BIOLOGY | 2014年 / 24卷 / 11期

基金：

英国惠康基金;

关键词：

Brd4; p65; NF-kappa B; enhancer; super-enhancer; inflammation; JQl; BET bromodomain; TRANSCRIPTION FACTORS; MACROPHAGE; ENHANCERS; CELLS;

D O I：

10.1016/j.tcb.2014.09.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Enhancer landscapes are shaped by the integrated functions of lineage-specific and signal-dependent transcription factors. A new study by Brown et al. suggests that the signal-dependent transcription factor NF-kappa B can modulate global enhancer activities by altering the occupancy of Brd4, a BET bromodomain coactivator protein, across the genome. This work reveals new principles of enhancer dynamics and insights into the therapeutic modulation of enhancer function with BET bromodomain inhibitors.

引用

页码：615 / 616

页数：2

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