MicroRNAs: The Role in Autoimmune Inflammation

被引：77

作者：

Baulina, N. M. ^{[1
,2
]}

Kulakova, O. G. ^{[1
,2
]}

Favorova, O. O. ^{[1
,2
]}

机构：

[1] Pirogov Russian Natl Res Med Univ, Ostrovityanova St 1, Moscow 117997, Russia

[2] Russian Cardiol Res & Prod Complex, 3-Rd Cherepkovskay St,15a, Moscow 121552, Russia

来源：

ACTA NATURAE | 2016年 / 8卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

microRNA; autoimmune inflammation; multiple sclerosis; T-CELL-ACTIVATION; MULTIPLE-SCLEROSIS; TH17; DIFFERENTIATION; ALTERED EXPRESSION; GENE-EXPRESSION; RNA EXPRESSION; B-LYMPHOCYTES; STEM-CELLS; PATHOGENESIS; ENCEPHALOMYELITIS;

D O I：

10.32607/20758251-2016-8-1-21-33

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-transcriptional level through base-pairing predominantly with a 3'-untranslated region of target mRNA, followed by mRNA degradation or translational repression. Totally, miRNAs change, through a complex regulatory network, the expression of more than 60% of human genes. MiRNAs are key regulators of the immune response that affect maturation, proliferation, differentiation, and activation of immune cells, as well as antibody secretion and release of inflammatory mediators. Disruption of this regulation may lead to the development of various pathological conditions, including autoimmune inflammation. This review summarizes the data on biogenesis and the mechanisms of miRNA action. We discuss the role of miRNAs in the development and the action of the immune system, as well as in the development of an autoimmune inflammatory response. Special attention is given to the role of miRNAs in the autoimmune inflammation in multiple sclerosis, which is a serious socially significant disease of the central nervous system. Currently, a lot of research is focused on this problem.

引用

页码：21 / 33

页数：13

共 75 条

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