Regioselective C-H Trifluoromethylation of Aromatic Compounds by Inclusion in Cyclodextrins

被引：16

作者：

Lu, Xu ^{[1
]}

Kawazu, Ryohei ^{[1
]}

Song, Jizhou ^{[1
]}

Yoshigoe, Yusuke ^{[2
]}

Torigoe, Takeru ^{[1
,2
]}

Kuninobu, Yoichiro ^{[1
,2
]}

机构：

[1] Kyushu Univ, Interdisciplinary Grad Sch Engn Sci, Dept Mol & Mat Sci, Kasuga, Fukuoka 8168580, Japan

[2] Kyushu Univ, Inst Mat Chem & Engn, Kasuga, Fukuoka 8168580, Japan

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 11期

关键词：

ARENES;

D O I：

10.1021/acs.orglett.1c01259

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A regioselective radical C-H trifluoromethylation of aromatic compounds was developed using cyclodextrins (CDs) as additives. The C-H trifluoromethylation proceeded with high regioselectivity to afford the product in good yield, even on the gram scale. In the presence of CDs, some substrates underwent a single trifluoromethylation selectively, whereas mixtures of single- and double-trifluoromethylated products were formed in the absence of the CD. H-1 NMR experiments indicated that the regioselectivity was controlled by the inclusion of a substrate inside the CD cavity.

引用

页码：4327 / 4331

页数：5

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