SARS-CoV-2 infection in acute pancreatitis increases disease severity and 30-day mortality: COVID PAN collaborative study

被引：66

作者：

Pandanaboyana, Sanjay ^{[1
,2
]}

Moir, John ^{[1
]}

Leeds, John S. ^{[1
,2
]}

Oppong, Kofi ^{[1
,3
]}

Kanwar, Aditya ^{[4
]}

Marzouk, Ahmed ^{[5
]}

Belgaumkar, Ajay ^{[6
]}

Gupta, Ajay ^{[7
]}

Siriwardena, Ajith K. ^{[8
]}

Haque, Ali Raza ^{[9
]}

Awan, Altaf ^{[10
]}

Balakrishnan, Anita ^{[11
]}

Rawashdeh, Arab ^{[12
]}

Ivanov, Bogdan ^{[13
]}

Parmar, Chetan ^{[14
]}

Halloran, Christopher M. ^{[15
]}

Caruana, Clifford ^{[16
]}

Borg, Cynthia-Michelle ^{[17
]}

Gomez, Dhanny ^{[18
]}

Damaskos, Dimitrios ^{[19
]}

Karavias, Dimitrios ^{[20
]}

Finch, Guy ^{[21
]}

Ebied, Husam ^{[22
]}

Pine, James K. ^{[23
]}

Skipworth, James R. A. ^{[24
]}

Milburn, James ^{[25
]}

Latif, Javed ^{[10
]}

Apollos, Jeyakumar Ratnam ^{[26
]}

El Kafsi, Jihene ^{[27
]}

Windsor, John A. ^{[28
]}

Roberts, Keith ^{[29
]}

Wang, Kelvin ^{[30
]}

Ravi, Krish ^{[31
]}

Coats, Maria, V ^{[32
]}

Hollyman, Marianne ^{[33
]}

Phillips, Mary ^{[34
]}

Okocha, Michael ^{[35
]}

Wilson, Michael S. J. ^{[36
]}

Ameer, Nadeem A. ^{[37
]}

Kumar, Nagappan ^{[38
]}

Shah, Nehal ^{[39
]}

Lapolla, Pierfrancesco ^{[40
]}

Magee, Connor ^{[41
]}

Al-Sarireh, Bilal ^{[42
]}

Lunevicius, Raimundas ^{[43
]}

Benhmida, Rami ^{[14
]}

Singhal, Rishi ^{[44
]}

Balachandra, Srinivasan ^{[45
]}

Atici, Semra Demirli ^{[46
]}

Jaunoo, Shameen ^{[47
]}

机构：

[1] Freeman Rd Hosp, HPB Unit, Newcastle Upon Tyne, Tyne & Wear, England

[2] Newcastle Univ, Populat Hlth Sci Inst, Newcastle Upon Tyne, Tyne & Wear, England

[3] Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England

[4] Univ Hosp Plymouth NHS Trust, Plymouth, Devon, England

[5] Altnagelvin Hosp, Derry, Londonderry, North Ireland

[6] East Surrey Hosp, Redhill, Surrey, England

[7] South Bristol Community Hosp, Bristol, Avon, England

[8] Manchester Royal Infirm, Manchester, Lancs, England

[9] Frimley Pk Hosp, Camberley, England

[10] Derby Hosp, Derby, England

[11] Addenbrookes Hosp, Cambridge, England

[12] Heartland Hosp Birmingham, Birmingham, W Midlands, England

[13] Princess Alexandra Hosp, Harlow, Essex, England

[14] Whittington Hosp, London, England

[15] Royal Liverpool Hosp, Liverpool, Merseyside, England

[16] Mater dei Hosp, Msida, Malta

[17] Univ Hosp Lewisham, Lewisham, England

[18] Nottingham City Hosp, Nottingham, England

[19] Royal Infirm Edinburgh NHS Trust, Edinburgh, Midlothian, Scotland

[20] Southampton Gen Hosp, Southampton, Hants, England

[21] Northampton Gen Hosp, Northampton, England

[22] St Thomas Hosp, London, England

[23] St James Univ Hosp, Leeds, W Yorkshire, England

[24] Bristol Royal Infirm & Gen Hosp, Bristol, Avon, England

[25] Aberdeen Royal Infirm, Aberdeen, Scotland

[26] Dumfries & Galloway Royal Infirm, Dumfries, Scotland

[27] Wexham Pk Hosp, Camberley, England

[28] Auckland City Hosp, Auckland, New Zealand

[29] Queen Elizabeth Hosp, Birmingham, W Midlands, England

[30] Wigan & Leigh NHS Fdn Trust, Wigan, England

[31] Chesterfield Royal Hosp NHS Trust, Chesterfield, England

[32] Glasgow Royal Infirm, Glasgow, Lanark, Scotland

[33] Musgrove Pk Hosp, Taunton, Somerset, England

[34] Royal Surrey Cty Hosp, Guildford, Surrey, England

[35] North Bristol NHS Trust, Southmead Hosp, Bristol, Avon, England

[36] Forth Valley Royal Hosp, Larbert, England

[37] Univ Hosp Coventry & Warwickshire, Coventry, W Midlands, England

[38] Univ Hosp Wales, Cardiff, Wales

[39] Northern Gen Hosp, Sheffield, S Yorkshire, England

[40] Sapienza Univ Rome, Policlin Umberto I, Rome, Italy

[41] Arrowe Pk Hosp, Wirral, Merseyside, England

[42] Morriston Hosp, Swansea, W Glam, Wales

[43] Aintree Hosp, Liverpool, Merseyside, England

[44] Univ Hosp Birmingham NHS Fdn Trust, Birmingham, W Midlands, England

[45] Doncaster Royal Infirm, Doncaster, England

[46] Univ Hlth Sci Tepecik Training & Res Hosp, Dept Gen Surg, Izmir, Turkey

[47] Brighton & Sussex Univ Hosp NHS Trust, Brighton, E Sussex, England

[48] Gloucestershire Hosp NHS Fdn Trust, Gloucester, England

[49] Royal Gwent Hosp, Newport, Gwent, Wales

[50] South Warwickshire NHS Fdn Trust, Warwick, England

来源：

GUT | 2021年 / 70卷 / 06期

关键词：

CORONAVIRUS;

D O I：

10.1136/gutjnl-2020-323364

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objective There is emerging evidence that the pancreas may be a target organ of SARS-CoV-2 infection. This aim of this study was to investigate the outcome of patients with acute pancreatitis (AP) and coexistent SARS-CoV-2 infection. Design A prospective international multicentre cohort study including consecutive patients admitted with AP during the current pandemic was undertaken. Primary outcome measure was severity of AP. Secondary outcome measures were aetiology of AP, intensive care unit (ICU) admission, length of hospital stay, local complications, acute respiratory distress syndrome (ARDS), persistent organ failure and 30-day mortality. Multilevel logistic regression was used to compare the two groups. Results 1777 patients with AP were included during the study period from 1 March to 23 July 2020. 149 patients (8.3%) had concomitant SARS-CoV-2 infection. Overall, SARS-CoV-2-positive patients were older male patients and more likely to develop severe AP and ARDS (p<0.001). Unadjusted analysis showed that SARS-CoV-2-positive patients with AP were more likely to require ICU admission (OR 5.21, p<0.001), local complications (OR 2.91, p<0.001), persistent organ failure (OR 7.32, p<0.001), prolonged hospital stay (OR 1.89, p<0.001) and a higher 30-day mortality (OR 6.56, p<0.001). Adjusted analysis showed length of stay (OR 1.32, p<0.001), persistent organ failure (OR 2.77, p<0.003) and 30-day mortality (OR 2.41, p<0.04) were significantly higher in SARS-CoV-2 co-infection. Conclusion Patients with AP and coexistent SARS-CoV-2 infection are at increased risk of severe AP, worse clinical outcomes, prolonged length of hospital stay and high 30-day mortality.

引用

页码：1061 / 1069

页数：9

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