Role of Kruppel-like Factor 4 in Phenotypic Switching and Proliferation of Vascular Smooth Muscle Cells

被引：60

作者：

Zheng, Bin ^{[1
]}

Han, Mei ^{[1
]}

Wen, Jin-Kun ^{[1
]}

机构：

[1] Hebei Med Univ, Dept Biochem & Mol Biol, Shijiazhuang 050017, Peoples R China

来源：

IUBMB LIFE | 2010年 / 62卷 / 02期

关键词：

KLF4; phenotype; proliferation; Vascular smooth muscle cells; GROWTH-FACTOR; GENE-EXPRESSION; TRANSCRIPTIONAL REGULATOR; DIFFERENTIATION MARKERS; COMBINATORIAL CONTROL; EMERGING ROLE; SRF BINDING; IN-VIVO; MYOCARDIN; KRUPPEL-LIKE-FACTOR-4;

D O I：

10.1002/iub.298

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phenotypic switching and proliferation of vascular smooth muscle cells (VSMCs) are critical components in the development of many vascular proliferation diseases such as atherosclerosis and restenosis after percutaneous coronary interventions. Kruppel-like factor 4 (KLF4) has been shown to play a key role in VSMC proliferation and differentiation. The focus of this review is to provide an overview for understanding the physiological and pathobiological roles of KLF4 in phenotypic switching and proliferation of VSMCs. (C) 2009 IUBMB IUBMB Life, 62(2): 132-139, 2010

引用

页码：132 / 139

页数：8

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