Microglia of the Brain: Origin, Structure, Functions

被引：10
作者：
Alekseeva, O. S. [1 ,2 ]
Kirik, O. V. [2 ]
Gilerovich, E. G. [2 ]
Korzhevskii, D. E. [2 ]
机构：
[1] Russian Acad Sci, Sechenov Inst Evolutionary Physiol & Biochem, St Petersburg, Russia
[2] Inst Expt Med, St Petersburg, Russia
来源：
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY | 2019年 / 55卷 / 04期
关键词：
microglia; brain; neurogenesis; neuroinflammation; mammals; HIPPOCAMPAL NEUROGENESIS; COGNITIVE FUNCTION; CORPUS-CALLOSUM; PROGENITOR-CELL; GLIAL-CELLS; RAT-BRAIN; ADULT; RECEPTOR; MACROPHAGES; CNS;
D O I：
10.1134/S002209301904001X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The review summarizes data on microglyocytes in the brain of mammals. General characteristics and features of their structure, functions and molecular organization at different ontogenetic stages are addressed. A special focus is on various hypotheses of the origin of microglia and current ideas about the involvement of microglyocytes in the regulation of neurogenesis and neuroinflammation. The data of recent experimental studies on toxic effects on microglia are critically analyzed. We point out the prospects for using the methods of selective microglia depletion (replacement) in modeling neuropathologies. This approach is supposed to enable assessment of the microglial contribution to the development of adaptive and neurodegenerative processes.
引用
收藏
页码：257 / 268
页数：12
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