Impact of the Controlling Nutritional Status Score on the Prognosis After Curative Resection of Pancreatic Ductal Adenocarcinoma

被引：54

作者：

Kato, Yoshiyasu ^{[1
]}

Yamada, Suguru ^{[1
]}

Suenaga, Masaya ^{[1
]}

Takami, Hideki ^{[1
]}

Niwa, Yukiko ^{[1
]}

Hayashi, Masamichi ^{[1
]}

Iwata, Naoki ^{[1
]}

Kanda, Mitsuro ^{[1
]}

Tanaka, Chie ^{[1
]}

Nakayama, Goro ^{[1
]}

Koike, Masahiko ^{[1
]}

Fujiwara, Michitaka ^{[1
]}

Kodera, Yasuhiro ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Gastroenterol Surg Surg 2, Nagoya, Aichi, Japan

来源：

PANCREAS | 2018年 / 47卷 / 07期

关键词：

pancreatic ductal adenocarcinoma; CONUT score; prognostic factor; pancreatectomy; immune-nutritional status; clinical characteristics; RANDOMIZED CONTROLLED-TRIAL; STATUS CONUT SCORE; LYMPH-NODE RATIO; HEPATOCELLULAR-CARCINOMA; ADJUVANT CHEMOTHERAPY; CHOLESTEROL LEVELS; COLORECTAL-CANCER; LUNG-CANCER; SURVIVAL; SURGERY;

D O I：

10.1097/MPA.0000000000001105

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives The controlling nutritional status (CONUT) score is a useful tool to evaluate immune-nutritional status. This study aimed to investigate the impact of the CONUT score on short- and long-term outcomes after curative resection of pancreatic ductal adenocarcinoma (PDAC). Methods Consecutive 344 PDAC patients receiving pancreatectomy without neoadjuvant therapy were examined retrospectively. After the best predictive value of the CONUT score for survival was identified, association between the CONUT score and long-term outcomes was evaluated using log-rank tests and a Cox regression model. Then correlations between the CONUT score and postoperative complications were analyzed. Results The optimal cutoff value of the CONUT score was 4. The high CONUT score group showed significantly lower overall survival than the low CONUT score group (P = 0.002). In contrast, no significant difference in recurrence-free survival was found (P = 0.43). A multivariate analysis demonstrated that high CONUT score had an independent association with overall survival (hazard ratio, 1.64; P = 0.003). The CONUT score showed no association with postoperative pancreatic fistula, Clavien-Dindo grade, or postoperative hospital stay. Conclusion The CONUT score had an independent association with survival in patients with PDAC after pancreatectomy and was not associated with recurrence or postoperative complications.

引用

页码：823 / 829

页数：7

共 54 条

[1] Inflammatory response related scoring systems in assessing the prognosis of patients with pancreatic ductal adenocarcinoma: a systematic review [J].