Mechanisms of Normal Tissue Injury From Irradiation

被引：96

作者：

Citrin, Deborah E. ^{[1
]}

Mitchell, James B. ^{[1
]}

机构：

[1] NCI, Radiat Oncol Branch, Ctr Canc Res, NIH, Bldg 10, Bethesda, MD 20892 USA

来源：

SEMINARS IN RADIATION ONCOLOGY | 2017年 / 27卷 / 04期

基金：

美国国家卫生研究院;

关键词：

GROWTH-FACTOR-BETA; INDUCED LUNG INJURY; CATALYTIC METALLOPORPHYRIN ANTIOXIDANT; ELEMENT-MEDIATED EXPRESSION; RADIATION-INDUCED FIBROSIS; INDUCED PULMONARY-FIBROSIS; TGF-BETA; T-CELLS; SUPEROXIDE-DISMUTASE; PHYSIOLOGICAL FRAILTY;

D O I：

10.1016/j.semradonc.2017.04.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Normal tissue injury from irradiation is an unfortunate consequence of radiotherapy. Technologic improvements have reduced the risk of normal tissue injury; however, toxicity causing treatment breaks or long-term side effects continues to occur in a subset of patients. The molecular events that lead to normal tissue injury are complex and span a variety of biologic processes, including oxidative stress, inflammation, depletion of injured cells, senescence, and elaboration of proinflammatory and profibrogenic cytokines. This article describes selected recent advances in normal tissue radiobiology. Published by Elsevier Inc.

引用

页码：316 / 324

页数：9

共 110 条

[11]

AWWAD M, 1988, CANCER IMMUNOL IMMUN, V26, P55

[12] Redox-mediated activation of latent transforming growth factor-beta 1 [J].

BarcellosHoff, MH ;

Dix, TA .

MOLECULAR ENDOCRINOLOGY, 1996, 10 (09) :1077-1083

[13] EVIDENCE FOR MOUSE TH1-LIKE AND TH2-LIKE HELPER T-CELLS INVIVO - SELECTIVE REDUCTION OF TH1-LIKE CELLS AFTER TOTAL LYMPHOID IRRADIATION [J].

BASS, H ;

MOSMANN, T ;

STROBER, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (05) :1495-1511

[14] A novel model of megavoltage radiation-induced oral mucositis in hamsters: Role of inflammatory cytokines and nitric oxide [J].

Bastos Moura, Jose Fernando ;

Segundo Correia Mota, Jose Mauricio ;

Vitorino Leite, Caio Abner ;

Wong, Deysi Viviana T. ;

Bezerra, Nilfacio Prado ;

De Castro Brito, Gerly Anne ;

Lima, Vilma ;

Cunha, Fernando Queiroz ;

Ribeiro, Ronaldo Albuquerque .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2015, 91 (06) :500-509

[15] Amelioration of radiation-induced lung injury by halofuginone: An experimental study in Wistar-Albino rats [J].

Calik, M. ;

Yavas, G. ;

Calik, S. G. ;

Yavas, C. ;

Celik, Z. E. ;

Sargon, M. F. ;

Esme, H. .

HUMAN & EXPERIMENTAL TOXICOLOGY, 2017, 36 (06) :638-647

[16] Genistein Can Mitigate the Effect of Radiation on Rat Lung Tissue [J].

Calveley, Victoria L. ;

Jelveh, Salomeh ;

Langan, Aimee ;

Mahmood, Javed ;

Yeung, Ivan W. T. ;

Van Dyk, Jake ;

Hill, Richard P. .

RADIATION RESEARCH, 2010, 173 (05) :602-611

[17] New insights into the molecular pathology of radiation-induced pneumopathy [J].

Cappuccini, Federica ;

Eldh, Therese ;

Bruder, Dunja ;

Gereke, Marcus ;

Jastrow, Holger ;

Schulze-Osthoff, Klaus ;

Fischer, Ute ;

Koehler, David ;

Stuschke, Martin ;

Jendrossek, Verena .

RADIOTHERAPY AND ONCOLOGY, 2011, 101 (01) :86-92

[18] Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice [J].

Chang, Jianhui ;

Wang, Yingying ;

Shao, Lijian ;

Laberge, Remi-Martin ;

Demaria, Marco ;

Campisi, Judith ;

Janakiraman, Krishnamurthy ;

Sharpless, Norman E. ;

Ding, Sheng ;

Feng, Wei ;

Luo, Yi ;

Wang, Xiaoyan ;

Aykin-Burns, Nukhet ;

Krager, Kimberly ;

Ponnappan, Usha ;

Hauer-Jensen, Martin ;

Meng, Aimin ;

Zhou, Daohong .

NATURE MEDICINE, 2016, 22 (01) :78-+

[19] Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: A new therapeutic approach for the treatment of inflammatory diseases [J].

Chen, XL ;

Kunsch, C .

CURRENT PHARMACEUTICAL DESIGN, 2004, 10 (08) :879-891

[20] Effects of NOX1 on fibroblastic changes of endothelial cells in radiation-induced pulmonary fibrosis [J].

Choi, Seo-Hyun ;

Kim, Miseon ;

Lee, Hae-June ;

Kim, Eun-Ho ;

Kim, Chun-Ho ;

Lee, Yoon-Jin .

MOLECULAR MEDICINE REPORTS, 2016, 13 (05) :4135-4142

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