Mechanisms of Normal Tissue Injury From Irradiation

被引：96
作者：
Citrin, Deborah E. [1 ]
Mitchell, James B. [1 ]
机构：
[1] NCI, Radiat Oncol Branch, Ctr Canc Res, NIH, Bldg 10, Bethesda, MD 20892 USA
来源：
SEMINARS IN RADIATION ONCOLOGY | 2017年 / 27卷 / 04期
基金：
美国国家卫生研究院;
关键词：
GROWTH-FACTOR-BETA; INDUCED LUNG INJURY; CATALYTIC METALLOPORPHYRIN ANTIOXIDANT; ELEMENT-MEDIATED EXPRESSION; RADIATION-INDUCED FIBROSIS; INDUCED PULMONARY-FIBROSIS; TGF-BETA; T-CELLS; SUPEROXIDE-DISMUTASE; PHYSIOLOGICAL FRAILTY;
D O I：
10.1016/j.semradonc.2017.04.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Normal tissue injury from irradiation is an unfortunate consequence of radiotherapy. Technologic improvements have reduced the risk of normal tissue injury; however, toxicity causing treatment breaks or long-term side effects continues to occur in a subset of patients. The molecular events that lead to normal tissue injury are complex and span a variety of biologic processes, including oxidative stress, inflammation, depletion of injured cells, senescence, and elaboration of proinflammatory and profibrogenic cytokines. This article describes selected recent advances in normal tissue radiobiology. Published by Elsevier Inc.
引用
收藏
页码：316 / 324
页数：9
相关论文
共 110 条
[1]   Targeting the TGFβ signalling pathway in disease [J].
Akhurst, Rosemary J. ;
Hata, Akiko .
NATURE REVIEWS DRUG DISCOVERY, 2012, 11 (10) :790-811
[2]   IL-17 and neutrophils: unexpected players in the type 2 immune response [J].
Allen, Judith E. ;
Sutherland, Tara E. ;
Rueckerl, Dominik .
CURRENT OPINION IN IMMUNOLOGY, 2015, 34 :99-106
[3]   Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors [J].
Anderton, Mark J. ;
Mellor, Howard R. ;
Bell, Alex ;
Sadler, Claire ;
Pass, Martin ;
Powell, Steve ;
Steele, Samantha J. ;
Roberts, Ruth. R. A. ;
Heier, Annabelle .
TOXICOLOGIC PATHOLOGY, 2011, 39 (06) :916-924
[4]   Small molecular inhibitor of transforming growth factor-β protects against development of radiation-induced lung injury [J].
Anscher, Mitchell S. ;
Thrasher, Bradley ;
Zgonjanin, Larisa ;
Rabbani, Zahid N. ;
Corbley, Michael J. ;
Fu, Kai ;
Sun, Lihong ;
Lee, Wen-Cherng ;
Ling, Leona E. ;
Vujaskovic, Zeljko .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2008, 71 (03) :829-837
[5]   Antitransforming growth factor-β antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation [J].
Anscher, MS ;
Thrasher, B ;
Rabbani, Z ;
Teicher, B ;
Vujaskovic, Z .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2006, 65 (03) :876-881
[6]   Plasma transforming growth factor β1 as a predictor of radiation pneumonitis [J].
Anscher, MS ;
Kong, FM ;
Andrews, K ;
Clough, R ;
Marks, LB ;
Bentel, G ;
Jirtle, RL .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1998, 41 (05) :1029-1035
[7]   Changes in plasma transforming growth factor beta during radiotherapy and the risk of symptomatic radiation-induced pneumonitis [J].
Anscher, MS ;
Kong, FM ;
Marks, LB ;
Bentel, GC ;
Jirtle, RL .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1997, 37 (02) :253-258
[8]   Risk of long-term complications after TGF-β1-guided very-high-dose thoracic radiotherapy [J].
Anscher, MS ;
Marks, LB ;
Shafman, TD ;
Clough, R ;
Huang, H ;
Tisch, A ;
Munley, M ;
Herndon, JE ;
Garst, J ;
Crawford, J ;
Jirtle, RL .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2003, 56 (04) :988-995
[9]   CHANGES IN PLASMA TGF-BETA LEVELS DURING PULMONARY RADIOTHERAPY AS A PREDICTOR OF THE RISK OF DEVELOPING RADIATION PNEUMONITIS [J].
ANSCHER, MS ;
MURASE, T ;
PRESCOTT, DM ;
MARKS, LB ;
REISENBICHLER, H ;
BENTEL, GC ;
SPENCER, D ;
SHEROUSE, G ;
JIRTLE, RL .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1994, 30 (03) :671-676
[10]   Physiologic Frailty in Nonelderly Hematopoietic Cell Transplantation Patients Results From the Bone Marrow Transplant Survivor Study [J].
Arora, Mukta ;
Sun, Can-Lan ;
Ness, Kirsten K. ;
Teh, Jennifer Berano ;
Wu, Jessica ;
Francisco, Liton ;
Armenian, Saro H. ;
Schad, Amy ;
Namdar, Golnaz ;
Bosworth, Alysia ;
Kuo, Linus ;
Weisdorf, Daniel J. ;
Forman, Stephen J. ;
Bhatia, Smita .
JAMA ONCOLOGY, 2016, 2 (10) :1277-1286
12345678910