Vitamin D3 supplementation: Response and predictors of vitamin D3 metabolites - A randomized controlled trial

被引:27
作者
Lehmann, Ulrike [1 ]
Riedel, Annett [1 ]
Hirche, Frank [1 ]
Brandsch, Corinna [1 ]
Girndt, Matthias [2 ]
Ulrich, Christof [2 ]
Seibert, Eric [2 ]
Henning, Christian [3 ]
Glomb, Marcus A. [3 ]
Dierkes, Jutta [4 ]
Stangl, Gabriele I. [1 ]
机构
[1] Univ Halle Wittenberg, Inst Agr & Nutr Sci, Halle, Germany
[2] Univ Halle Wittenberg, Dept Internal Med 2, Halle, Germany
[3] Univ Halle Wittenberg, Food Chem, Inst Chem, Halle, Germany
[4] Univ Bergen, Dept Clin Med, N-5020 Bergen, Norway
关键词
Vitamin D; 25(OH)D-3; 24,25(OH)(2)D-3; Supplementation; Healthy subjects; Randomized controlled trial; SERUM 25-HYDROXYVITAMIN D; GENETIC-DETERMINANTS; BIOAVAILABILITY; DIETARY; WOMEN; D-3; CALCIUM; CANCER;
D O I
10.1016/j.clnu.2015.04.021
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background & aims: Large parts of the population are insufficiently supplied with vitamin D, in particular when endogenous synthesis is absent. Therefore many health care providers recommend the use of vitamin D supplements. The current study aimed to investigate the efficacy of an once-daily oral dose of 20 mu g vitamin D-3 to improve the vitamin D status and to evaluate predictors of response. Methods: The study was conducted as a double-blind, randomized, placebo-controlled parallel trial from January till April 2013. In total, 105 subjects (2-71 years) were allocated to receive either a vitamin D-3 supplement (20 mu g/d) or a placebo for 12 weeks. Circulating levels of vitamin D-3 metabolites such as the 25(OH)D-3 and the 24,25(OH)(2)D-3, and biomarkers of calcium and phosphate metabolism were quantified. Results: The 25(OH)D-3 serum concentrations in the placebo group decreased from 38 +/- 15 nmol/L at baseline to 32 +/- 14 nmol/L and 32 +/- 13 nmol/L at weeks 8 and 12 of the study, respectively (p < 0.01). In the vitamin D-3 group, the serum 25(OH)D-3 concentration increased from 38 +/- 14 nmol/L at baseline to 70 +/- 15 nmol/L and 73 +/- 16 nmol/L at weeks 8 and 12 of vitamin D-3 supplementation (p < 0.001), respectively. As a result, 94% of the vitamin D-3-supplemented participants reached 25(OH)D-3 concentrations of >= 50 nmol/L and thereof 46% attained 25(OH)D-3 levels of >= 75 nmol/L until the end of the study. The extent of the 25(OH)D-3 increase upon vitamin D-3 supplementation depended on 25(OH)D-3 baseline levels, age, body weight and circulating levels of triglycerides. In contrast to 25(OH)D-3, the response of 24,25(OH)(2)D-3 to the vitamin D-3 treatment was affected only by baseline levels of 24,25(OH)(2)D-3 and age. Conclusions: The average improvement of 25(OH)D-3 levels in individuals who received 20 mu g vitamin D-3 per day during the winter months was 41 nmol/L compared to individuals without supplementation. As a result almost all participants with the vitamin D-3 supplementation attained 25(OH)D-3 concentrations of 50 nmol/L and higher. The suitability of 24,25(OH)(2)D-3 as a marker of vitamin D status needs further investigation. (C) 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
引用
收藏
页码:351 / 358
页数:8
相关论文
共 30 条
[1]   New Reference Values for Vitamin D [J].
不详 .
ANNALS OF NUTRITION AND METABOLISM, 2012, 60 (04) :241-246
[2]   Body fat content and 25-hydroxyvitamin D levels in healthy women [J].
Arunabh, S ;
Pollack, S ;
Yeh, J ;
Aloia, JF .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (01) :157-161
[3]   Human 25-hydroxyvitamin D3-24-hydroxylase, a multicatalytic enzyme [J].
Beckman, MJ ;
Tadikonda, P ;
Werner, E ;
Prahl, J ;
Yamada, S ;
DeLuca, HF .
BIOCHEMISTRY, 1996, 35 (25) :8465-8472
[4]  
BHATTACHARYYA MH, 1973, J BIOL CHEM, V248, P2969
[5]   Body size and serum 25 hydroxy vitamin D response to oral supplements in healthy older adults [J].
Blum, Miriam ;
Dallal, Gerard E. ;
Dawson-Hughes, Bess .
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2008, 27 (02) :274-279
[6]   Dietary calcium does not interact with vitamin D3 in terms of determining the response and catabolism of serum 25-hydroxyvitamin D during winter in older adults [J].
Cashman, Kevin D. ;
Hayes, Aoife ;
O'Donovan, Sinead M. ;
Zhang, Joy Y. ;
Kinsella, Michael ;
Galvin, Karen ;
Kiely, Mairead ;
Seamans, Kelly M. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2014, 99 (06) :1414-1423
[7]   Estimation of the dietary requirement for vitamin D in healthy adults [J].
Cashman, Kevin D. ;
Hill, Tom R. ;
Lucey, Alice J. ;
Taylor, Nicola ;
Seamans, Kelly M. ;
Muldowney, Siobhan ;
FitzGerald, Anthony P. ;
Flynn, Albert ;
Barnes, Maria S. ;
Horigan, Geraldine ;
Bonham, Maxine P. ;
Duffy, Emeir M. ;
Strain, J. J. ;
Wallace, Julie M. W. ;
Kiely, Mairead .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2008, 88 (06) :1535-1542
[8]   Long-Term Bioavailability After a Single Oral or Intramuscular Administration of 600,000 IU of Ergocalciferol or Cholecalciferol: Implications for Treatment and Prophylaxis [J].
Cipriani, Cristiana ;
Romagnoli, Elisabetta ;
Pepe, Jessica ;
Russo, Stefania ;
Carlucci, Luciano ;
Piemonte, Sara ;
Nieddu, Luciano ;
McMahon, Donald J. ;
Singh, Ravinder ;
Minisola, Salvatore .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (07) :2709-2715
[9]   The serum 25-hydroxyvitamin D response to vitamin D supplementation is related to genetic factors, BMI, and baseline levels [J].
Didriksen, Allan ;
Grimnes, Guri ;
Hutchinson, Moira Strand ;
Kjaergaard, Marie ;
Svartberg, Johan ;
Joakimsen, Ragnar M. ;
Jorde, Rolf .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2013, 169 (05) :559-567
[10]   G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences [J].
Faul, Franz ;
Erdfelder, Edgar ;
Lang, Albert-Georg ;
Buchner, Axel .
BEHAVIOR RESEARCH METHODS, 2007, 39 (02) :175-191