Modulation of cortical circuits by top-down processing and arousal state in health and disease

被引：29

作者：

Batista-Brito, Renata ^{[1
]}

Zagha, Edward ^{[2
]}

Ratliff, Check For Jacob M. ^{[1
]}

Vinck, Martin ^{[3
]}

机构：

[1] Albert Einstein Coll Med, Rose F Kennedy Ctr, Dominick P Purpura Dept Neurosci, 1410 Pelham Pkwy South Room 203, Bronx, NY 10461 USA

[2] Univ Calif Riverside, Dept Psychol, 900 Univ Ave, Riverside, CA 92521 USA

[3] Ernst Struengmann Inst Neurosci Cooperat Max Plan, Deutschordenstr 46, D-60528 Frankfurt, Germany

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2018年 / 52卷

关键词：

GAMMA-BAND SYNCHRONIZATION; VISUAL-CORTEX; ATTENTIONAL MODULATION; SOMATOSTATIN INTERNEURONS; GABAERGIC INTERNEURONS; SOMATOSENSORY CORTEX; INHIBITORY CIRCUITS; SPATIAL ATTENTION; MOTOR CORTEX; IN-VIVO;

D O I：

10.1016/j.conb.2018.06.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this review, we explore how contextual modulations of sensory processing are implemented within the local cortical circuit. We focus on contextual influences of global arousal state (e.g. how alert am I?), sensory predictions (e.g. which stimuli do I expect?), and top-down attention (what is relevant to me?). We review recent literature suggesting that these operations are implemented throughout sensory cortices, and are mediated by excitatory and inhibitory local circuits. By focusing on the circuit mechanisms of contextual modulation operations, we may begin to understand how mutations in GABAergic interneurons and alterations in neuromodulatory signaling lead to specific deficits of information processing in neuropsychiatric disease.

引用

页码：172 / 181

页数：10

共 79 条

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