Cryptorchidism: Pathogenesis, Diagnosis, Treatment and Prognosis

被引:58
作者
Ashley, Richard A. [2 ]
Barthold, Julia S. [2 ,3 ]
Kolon, Thomas F. [1 ]
机构
[1] Childrens Hosp Philadelphia, Div Pediat Urol, Philadelphia, PA 19104 USA
[2] Nemours Alfred I DuPont Hosp Children, Div Pediat Urol, Wilmington, DE 19803 USA
[3] Thomas Jefferson Univ, Jefferson Med Coll, Dept Urol, Philadelphia, PA 19107 USA
关键词
Cryptorchidism; Testis; Pathogenesis; Diagnosis; ANDROGEN RECEPTOR GENE; PALPABLE UNDESCENDED TESTIS; TESTICULAR DYSGENESIS SYNDROME; SCROTAL INCISION ORCHIOPEXY; GERM-CELL DEVELOPMENT; HUMAN BREAST-MILK; NONPALPABLE TESTIS; FACTOR-3; LEVELS; RISK-FACTORS; CONGENITAL CRYPTORCHIDISM;
D O I
10.1016/j.ucl.2010.03.002
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Cryptorchidism is a common genital anomaly diagnosed at birth or during childhood. Genetic and/or environmental factors that alter expression or function of hormones crucial for testicular descent, insulin-like 3, and testosterone, may contribute to cryptorchidism. When identified at birth, surgical treatment is indicated by 6 months of age if testes fail to descend, or at the time of diagnosis in older children. A laparoscopic approach is preferred for abdominal testes. Early surgical therapy may reduce the risk of subfertility and/or malignancy.
引用
收藏
页码:183 / +
页数:13
相关论文
共 139 条
[1]   The descriptive epidemiology of congenital and acquired cryptorchidism in a UK infant cohort [J].
Acerini, C. L. ;
Miles, H. L. ;
Dunger, D. B. ;
Ong, K. K. ;
Hughes, I. A. .
ARCHIVES OF DISEASE IN CHILDHOOD, 2009, 94 (11) :868-872
[2]   Retractile testis - Is it really a normal variant? [J].
Agarwal, PK ;
Diaz, M ;
Elder, JS .
JOURNAL OF UROLOGY, 2006, 175 (04) :1496-1499
[3]   Risk of contralateral testicular cancer among men with unilaterally undescended testis: A meta analysis [J].
Akre, Olof ;
Pettersson, Andreas ;
Richiardi, Lorenzo .
INTERNATIONAL JOURNAL OF CANCER, 2009, 124 (03) :687-689
[4]   Does a testicular dysgenesis syndrome exist? [J].
Akre, Olof ;
Richiardi, Lorenzo .
HUMAN REPRODUCTION, 2009, 24 (09) :2053-2060
[5]   Potential complications with the prescrotal approach for the palpable undescended testis? A comparison of single prescrotal incision to the traditional inguinal approach [J].
Al-Mandil, Majid ;
Khoury, Antoine E. ;
Ei-Hout, Yaser ;
Kogon, Michael ;
Dave, Sumit ;
Farhat, Walid A. .
JOURNAL OF UROLOGY, 2008, 180 (02) :686-689
[6]   Insulin-like factor 3 levels in amniotic fluid of human male fetuses [J].
Anand-Ivell, Ravinder ;
Ivell, Richard ;
Driscoll, Deborah ;
Manson, Jeanne .
HUMAN REPRODUCTION, 2008, 23 (05) :1180-1186
[7]   Linkage between cryptorchidism, hypospadias, and GGN repeat length in the androgen receptor gene [J].
Aschim, EL ;
Nordenskjöld, A ;
Giwercman, A ;
Lundin, KB ;
Ruhayel, Y ;
Haugen, TB ;
Grotmol, T ;
Giwercman, YL .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (10) :5105-5109
[8]   A multi-institutional analysis of laparoscopic orchidopexy [J].
Baker, LA ;
Docimo, SG ;
Surer, I ;
Peters, C ;
Cisek, L ;
Diamond, DA ;
Caldamone, A ;
Koyle, M ;
Strand, W ;
Moore, R ;
Mevorach, R ;
Brady, J ;
Jordan, G ;
Erhard, M ;
Franco, I .
BJU INTERNATIONAL, 2001, 87 (06) :484-489
[9]   Testicular position in the androgen insensitivity syndrome: Implications for the role of androgens in testicular descent [J].
Barthold, JS ;
Kumasi-Rivers, K ;
Upadhyay, J ;
Shekarriz, B ;
Imperato-McGinley, J .
JOURNAL OF UROLOGY, 2000, 164 (02) :497-501
[10]   Is adjuvant hormonal therapy indicated in cryptorchidism? [J].
Barthold, JS .
NATURE CLINICAL PRACTICE UROLOGY, 2005, 2 (08) :366-367