Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis

被引：57

作者：

Martin-Kleiner, Irena ^{[1
]}

Troselj, Koraljka Gall ^{[1
]}

机构：

[1] Rudjer Boskovic Inst, Div Mol Med, Lab Epigenom, Zagreb 10002, Croatia

来源：

CANCER LETTERS | 2010年 / 289卷 / 01期

关键词：

M6P/IGF2R; Loss of heterozygosity; Mutation; IGF2; Cancer; FACTOR-II RECEPTOR; MANNOSE 6-PHOSPHATE RECEPTOR; SQUAMOUS-CELL CARCINOMA; TUMOR-SUPPRESSOR GENE; BREAST-CANCER CELLS; PRIMARY HEPATOCELLULAR-CARCINOMA; MICROSATELLITE INSTABILITY; LIGAND-BINDING; PROSTATE-CANCER; IGF-II;

D O I：

10.1016/j.canlet.2009.06.036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulatecl in cancer. Its tumor suppressor role was recognized a long time ago. However, due to its multifunctionality, it is not easy to understand the extent of its relevance to normal cellular physiology. Accordingly, it is even more difficult understanding its role in carcinogenesis. This review presents critical and focused highlights of data relating to M6P/IGF2R, obtained during more than 25 years of cancer research. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：11 / 22

页数：12

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