Sepsis-Induced Immunosuppression

被引：200

作者：

Torres, Lisa K. ^{[1
]}

Pickkers, Peter ^{[2
]}

van der Poll, Tom ^{[3
]}

机构：

[1] Weill Cornell Med, New York Presbyterian Hosp, Dept Med, Div Pulm & Crit Care Med, New York, NY 10021 USA

[2] Radboud Univ Nijmegen, Dept Intens Care Med, Med Ctr, Nijmegen, Netherlands

[3] Univ Amsterdam, Amsterdam Univ Med Ctr, Ctr Expt & Mol Med, Div Infect Dis, Amsterdam, Netherlands

来源：

ANNUAL REVIEW OF PHYSIOLOGY | 2022年 / 84卷

基金：

欧盟地平线“2020”;

关键词：

TUMOR-NECROSIS-FACTOR; STIMULATING FACTOR THERAPY; PROGRAMMED CELL-DEATH; INTENSIVE-CARE-UNIT; SEPTIC SHOCK; IMPROVES SURVIVAL; T-CELLS; GM-CSF; EPIGENETIC REGULATION; SECONDARY INFECTIONS;

D O I：

10.1146/annurev-physiol-061121-040214

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Sepsis is expected to have a substantial impact on public health and cost as its prevalence increases. Factors contributing to increased prevalence include a progressively aging population, advances in the use of immunomodulatory agents to treat a rising number of diseases, and immune-suppressing therapies in organ transplant recipients and cancer patients. It is now recognized that sepsis is associated with profound and sustained immunosuppression, which has been implicated as a predisposing factor in the increased susceptibility of patients to secondary infections and mortality. In this review, we discuss mechanisms of sepsis-induced immunosuppression and biomarkers that identify a state of impaired immunity. We also highlight immune-enhancing strategies that have been evaluated in patients with sepsis, as well as therapeutics under current investigation. Finally, we describe future challenges and the need for a new treatment paradigm, integrating predictive enrichment with patient factors that may guide the future selection of tailored immunotherapy.

引用

页码：157 / 181

页数：25

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