Sepsis-Induced Immunosuppression

被引：171

作者：

Torres, Lisa K. ^{[1
]}

Pickkers, Peter ^{[2
]}

van der Poll, Tom ^{[3
]}

机构：

[1] Weill Cornell Med, New York Presbyterian Hosp, Dept Med, Div Pulm & Crit Care Med, New York, NY 10021 USA

[2] Radboud Univ Nijmegen, Dept Intens Care Med, Med Ctr, Nijmegen, Netherlands

[3] Univ Amsterdam, Amsterdam Univ Med Ctr, Ctr Expt & Mol Med, Div Infect Dis, Amsterdam, Netherlands

来源：

ANNUAL REVIEW OF PHYSIOLOGY | 2022年 / 84卷

基金：

欧盟地平线“2020”;

关键词：

TUMOR-NECROSIS-FACTOR; STIMULATING FACTOR THERAPY; PROGRAMMED CELL-DEATH; INTENSIVE-CARE-UNIT; SEPTIC SHOCK; IMPROVES SURVIVAL; T-CELLS; GM-CSF; EPIGENETIC REGULATION; SECONDARY INFECTIONS;

D O I：

10.1146/annurev-physiol-061121-040214

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Sepsis is expected to have a substantial impact on public health and cost as its prevalence increases. Factors contributing to increased prevalence include a progressively aging population, advances in the use of immunomodulatory agents to treat a rising number of diseases, and immune-suppressing therapies in organ transplant recipients and cancer patients. It is now recognized that sepsis is associated with profound and sustained immunosuppression, which has been implicated as a predisposing factor in the increased susceptibility of patients to secondary infections and mortality. In this review, we discuss mechanisms of sepsis-induced immunosuppression and biomarkers that identify a state of impaired immunity. We also highlight immune-enhancing strategies that have been evaluated in patients with sepsis, as well as therapeutics under current investigation. Finally, we describe future challenges and the need for a new treatment paradigm, integrating predictive enrichment with patient factors that may guide the future selection of tailored immunotherapy.

引用

页码：157 / 181

页数：25

共 142 条

[1] Reflex Principles of Immunological Homeostasis [J].

Andersson, Ulf ;

Tracey, Kevin J. .

ANNUAL REVIEW OF IMMUNOLOGY, VOL 30, 2012, 30 :313-335

[2] Sepsis-induced long-term immune paralysis - results of a descriptive, explorative study [J].

Arens, C. ;

Bajwa, S. A. ;

Koch, C. ;

Siegler, B. H. ;

Schneck, E. ;

Hecker, A. ;

Weiterer, S. ;

Lichtenstern, C. ;

Weigand, M. A. ;

Uhle, F. .

CRITICAL CARE, 2016, 20

[3] Intravenous immunoglobulin for adjunctive treatment of severe infections in ICUs [J].

Aubron, Cecile ;

Berteau, Florian ;

Sparrow, Rosemary L. .

CURRENT OPINION IN CRITICAL CARE, 2019, 25 (05) :417-422

[4] Endotoxin tolerance: new mechanisms, molecules and clinical significance [J].

Biswas, Subhra K. ;

Lopez-Collazo, Eduardo .

TRENDS IN IMMUNOLOGY, 2009, 30 (10) :475-487

[5] Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: a meta-analysis [J].

Bo, Lulong ;

Wang, Fei ;

Zhu, Jiali ;

Li, Jinbao ;

Deng, Xiaoming .

CRITICAL CARE, 2011, 15 (01)

[6]

Boomer JS, 2014, VIRULENCE, V5, P45, DOI [10.4161/viru.26516, 10.4161/viru.27794]

[7] Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure [J].

Boomer, Jonathan S. ;

To, Kathleen ;

Chang, Kathy C. ;

Takasu, Osamu ;

Osborne, Dale F. ;

Walton, Andrew H. ;

Bricker, Traci L. ;

Jarman, Stephen D., II ;

Kreisel, Daniel ;

Krupnick, Alexander S. ;

Srivastava, Anil ;

Swanson, Paul E. ;

Green, Jonathan M. ;

Hotchkiss, Richard S. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 306 (23) :2594-2605

[8] Innate Immune Modulation by GM-CSF and IL-3 in Health and Disease [J].

Borriello, Francesco ;

Galdiero, Maria Rosaria ;

Varricchi, Gilda ;

Loffredo, Stefania ;

Spadaro, Giuseppe ;

Marone, Gianni .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (04)

[9] Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis [J].

Brahmamdam, Pavan ;

Inoue, Shigeaki ;

Unsinger, Jacqueline ;

Chang, Katherine C. ;

McDunn, Jonathan E. ;

Hotchkiss, Richard S. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2010, 88 (02) :233-240

[10] IFN-γ: A cytokine at the right time, is in the right place [J].

Burke, J. Daniel ;

Young, Howard A. .

SEMINARS IN IMMUNOLOGY, 2019, 43

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