The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic Inflammatory Response to Severe Burn Injury

被引：27

作者：

Kim, Albert ^{[1
]}

Lang, Thomas ^{[1
]}

Xue, Meilang ^{[2
]}

Wijewardana, Aruna ^{[1
]}

Jackson, Chris ^{[2
]}

Vandervord, John ^{[1
]}

机构：

[1] Royal North Shore Hosp, Severe Burns Unit, St Leonards, NSW 2065, Australia

[2] Univ Sydney, Inst Bone & Joint Res, Sutton Arthrit Res Lab, Sydney, NSW 2006, Australia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 04期

关键词：

burns; inflammation; systemic inflammatory response; gamma delta T-cells; cytokines; NITRIC-OXIDE; UP-REGULATION; RECEPTORS;

D O I：

10.3390/ijms18040758

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Burns are a global public health problem, accounting for an estimated 265,000 deaths annually. Inflammation is essential in supplying the growth factors, cytokines and chemokines needed to recruit T-cells and myeloid cells to the site of a burn injury for wound healing. However, major burns generate a marked pathophysiological inflammatory response through a widespread release of abundant pro-inflammatory mediators that predispose patients to a systemic inflammatory response syndrome, sepsis and multi-organ failure. Recently, there has been promising investigation into the role of gamma delta T-cells and Th-17 cells in the regulation and propagation of this inflammatory response. This study reviews the current literature on the post-burn immune response.

引用

页数：6

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