Improvements in mechanical properties of collagen-based scaffolds for tissue engineering

被引：47

作者：

Gurumurthy, Bhuvaneswari ^{[1
]}

Janorkar, Amol, V ^{[1
]}

机构：

[1] Univ Mississippi, Sch Dent, Dept Biomed Mat Sci, Med Ctr, Jackson, MS 39216 USA

来源：

CURRENT OPINION IN BIOMEDICAL ENGINEERING | 2021年 / 17卷

关键词：

Hydrogels; Composites; Chemical crosslinking; Physical crosslinking; Mechanical behavior; ELASTIN-LIKE POLYPEPTIDE; CROSS-LINKING; GLYCOSAMINOGLYCAN SCAFFOLDS; COMPOSITE SCAFFOLDS; BONE REGENERATION; MEMBRANES; PROLIFERATION; ATTACHMENT; MIGRATION; STIFFNESS;

D O I：

10.1016/j.cobme.2020.100253

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

As the most abundant extracellular matrix protein in the human body, collagen has been a popular biomaterial to prepare tissue engineering scaffolds. Unfortunately, collagen-only scaffolds do not possess adequate mechanical properties (modulus, strength) for in vitro handling and long-term cell culture. This paper reviews the improvements in the mechanical properties of collagen-based scaffolds using the gelation process and crosslinking agents. Effects of both chemical and physical crosslinking methods on scaffold mechanical properties are discussed along with the effects of wet versus dry testing conditions. Approaches involving the addition of polymer and ceramic additives in the collagen-based scaffolds forming composites to enhance their mechanical properties are also summarized.

引用

页数：8

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