Amphiphilic Ionic Liquids Capable to Formulate Organized Systems in an Aqueous Solution, Designed by a Combination of Traditional Surfactants and Commercial Drugs

被引：5

作者：

Dib, Nahir ^{[1
,2
]}

Silber, Juana J. ^{[1
,2
]}

Correa, N. Mariano ^{[1
,2
]}

Falcone, R. Dario ^{[1
,2
]}

机构：

[1] Univ Nacl Rio Cuarto, Dept Quim, Agencia Postal 3,CP X5804BYA,Ruta Nacl 36,km 60, Cordoba, Argentina

[2] Univ Nacl Rio Cuarto, Inst Desarrollo Agroindustrial & Salud IDAS, Agencia Postal 3,CP X5804BYA,Ruta Nacl 36,km 60, Cordoba, Argentina

来源：

PHARMACEUTICAL RESEARCH | 2022年 / 39卷 / 10期

关键词：

Ionic liquids; Drug delivery system; Surfactant; SAILs; Vesicles; Micelles; CRITICAL AGGREGATION CONCENTRATION; CATANIONIC VESICLES; ANTICANCER DRUG; MOLECULAR-INTERACTIONS; UNILAMELLAR VESICLES; CATIONIC SURFACTANT; PROLONGED RELEASE; REVERSE MICELLES; PHASE-BEHAVIOR; AEROSOL-OT;

D O I：

10.1007/s11095-022-03342-7

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The present review describes the state of the art in the conversion of pharmaceutically active ingredients (API) in amphiphilic Ionic Liquids (ILs) as alternative drug delivery systems. In particular, we focus our attention on the compounds generated by ionic exchange and without original counterions which generate different systems in comparison with the simple mixtures. In water, these new amphiphiles show similar or even better properties as surfactants in comparison with their precursors. Cations such as 1-alkyl-3-methyl-imidazolium and anions such as dioctyl sulfosuccinate or sodium dodecyl sulfate appear as the amphiphilic components most studied. In conclusion, this work shows interesting information on several promissory compounds and they appear as an interesting challenge to extend the application of ILs in the medical field.

引用

页码：2379 / 2390

页数：12

共 117 条

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