Imatinib Mesylate in Children and Adolescents With Cancer

被引：24

作者：

Barr, Ronald D. ^{[1
]}

机构：

[1] McMaster Univ, Dept Pediat Pathol & Med, Hamilton, ON, Canada

来源：

PEDIATRIC BLOOD & CANCER | 2010年 / 55卷 / 01期

关键词：

adolescents; cancer; children; imatinib; CHRONIC MYELOID-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; GASTROINTESTINAL STROMAL TUMORS; GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITOR; ACUTE LYMPHOBLASTIC-LEUKEMIA; STEM-CELL TRANSPLANTATION; C-KIT; PHASE-II; DERMATOFIBROSARCOMA PROTUBERANS;

D O I：

10.1002/pbc.22484

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Imatinib is an inhibitor of the BCR-ABL fusion gene product that characterizes chronic myeloid leukemia (CML), and of the related tyrosine kinases c-KIT and platelet-derived growth factor (PDGF) receptor. The drug is now included as front-line therapy for CML and Philadelphia chromosome-positive acute lymphoblastic leukemia in children and adolescents, though valid concerns about serious late sequelae remain unresolved and are important issues for further study. European and North American consortia have conducted phase I and II clinical trials of imatinib in children and adolescents with brain and other solid tumors that have provided little evidence of efficacy. Pediatr Blood Cancer 2010;55:18-25. (C) 2010 Wiley-Liss, Inc.

引用

页码：18 / 25

页数：8

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