Epithelial-to-Mesenchymal Transitions and Circulating Tumor Cells

被引：235

作者：

Bonnomet, Arnaud ^{[1
,4
]}

Brysse, Anne ^{[4
]}

Tachsidis, Anthony ^{[2
,3
]}

Waltham, Mark ^{[2
]}

Thompson, Erik W. ^{[2
,3
]}

Polette, Myriam ^{[1
]}

Gilles, Christine ^{[4
]}

机构：

[1] CHU Maison Blanche, Unite INSERM UMR S 903, Lab Pol Bouin, IFR53, Reims, France

[2] St Vincents Inst, Melbourne, Vic, Australia

[3] Univ Melbourne, Dept Surg, St Vincents Hosp, Melbourne, Vic, Australia

[4] Univ Liege, GIGA Canc, Lab Tumor & Dev Biol, CHU Sart Tilman, B-4000 Liege, Belgium

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2010年 / 15卷 / 02期

关键词：

EMT; CTC; Metastases; BREAST-CANCER PATIENTS; ENDOTHELIAL GROWTH-FACTOR; MEMBRANE-TYPE-1; MATRIX-METALLOPROTEINASE; FINGER TRANSCRIPTION FACTOR; OVARIAN-CARCINOMA CELLS; E-CADHERIN EXPRESSION; NF-KAPPA-B; BETA-CATENIN; GENE-EXPRESSION; UP-REGULATION;

D O I：

10.1007/s10911-010-9174-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epithelial-to-mesenchymal transition (EMT) phenomena endow epithelial cells with enhanced migratory and invasive potential, and as such, have been implicated in many physiological and pathological processes requiring cell migration/invasion. Although their involvement in the metastatic cascade is still a subject of debate, data are accumulating to demonstrate the existence of EMT phenotypes in primary human tumors, describe enhanced metastatic potential of EMT derivatives in animal models, and report EMT attributes in circulating tumor cells (CTCs). The relationships between EMT and CTCs remain largely unexplored, and we review here in vitro and in vivo data supporting a putative role of EMT processes in CTC generation and survival.

引用

页码：261 / 273

页数：13

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