CTLA-4+49A/G gene polymorphism and type 1 diabetes mellitus in the Chinese population: a meta-analysis of 2238 subjects

被引：2
作者：
Li, Yan-yan [1 ]
Gong, Ge [1 ]
Geng, Hong-yu [1 ]
Yang, Zhi-jian [1 ,2 ]
Zhou, Chuan-wei [1 ]
Lu, Xin-zheng [2 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Geriatr, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing 210029, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES | 2016年 / 36卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Cytotoxic T lymphocyte-associated antigen 4; +49A/G; Polymorphism; Type 1 diabetes mellitus; A/G POLYMORPHISM; AUTOIMMUNE-DISEASE; CTLA4; LOCUS; ASSOCIATION; SUSCEPTIBILITY; VARIANT; CHILDREN; IDDM; ALLELES; BIAS;
D O I：
10.1007/s13410-015-0414-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Previous studies reported that cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) +49A/G gene polymorphism is correlated with type 1 diabetes mellitus (T1DM) risk. However, their results remain disputable. This study aims to discuss the relationship between CTLA-4 +49A/G gene polymorphism and T1DM in a Chinese population. The current meta-analysis involved 2238 participants from seven individual studies. The pooled odds ratio (OR) and its corresponding 95 % confidence interval (95 % CI) were assessed by the random- or fixed-effects model. A significant relationship between CTLA-4 +49A/G gene polymorphism and T1DM was detected under allelic (OR: 1.84, 95 % CI: 1.62-2.10, P < 0.00001), dominant (OR: 1.152, 95 % CI: 1.062-1.249, P = 0.001), recessive (OR: 1.631, 95 % CI: 1.443-1.844, P < 0.00001), and additive (OR: 1.292, 95 % CI: 1.224-1.363, P < 0.00001) genetic models. A significant relationship exists between CTLA-4 +49A/G gene polymorphism and increased T1DM risk in the Chinese population. Individuals having the G allele of CTLA-4 +49A/G gene polymorphism have a higher risk for T1DM in the Chinese population.
引用
收藏
页码：45 / 51
页数：7
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