Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress

被引：127

作者：

Sun, Jing ^{[1
]}

Wang, Fangyan ^{[2
]}

Hong, Guangliang ^{[3
]}

Pang, Mengqi ^{[4
]}

Xu, Hailing ^{[4
]}

Li, Haixiao ^{[4
]}

Tian, Feng ^{[4
]}

Fang, Renchi ^{[4
]}

Yao, Ye ^{[4
]}

Liu, Jiaming ^{[4
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Neurol, 109 Coll West Rd, Wenzhou 325027, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Dept Pathophysiol, 1210 Univ Town, Wenzhou 325035, Zhejiang, Peoples R China

[3] Wenzhou Med Univ, Affiliated Hosp 1, Dept Emergency, Wenzhou 325000, Zhejiang, Peoples R China

[4] Wenzhou Med Univ, Sch Environm Sci & Publ Hlth, 1210 Univ Town, Wenzhou 325035, Zhejiang, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2016年 / 618卷

关键词：

Sodium butyrate; Chronic unpredictable mild stress (CUMS); 5-HT; BDNF; Blood-brain barrier (BBB); Antidepressant; BLOOD-BRAIN-BARRIER; HISTONE DEACETYLASE INHIBITOR; DEPRESSIVE-LIKE BEHAVIOR; NEUROTROPHIC FACTOR; ALZHEIMERS-DISEASE; RAT MODEL; PARKINSONS-DISEASE; MAJOR DEPRESSION; GENE-EXPRESSION; MOUSE MODEL;

D O I：

10.1016/j.neulet.2016.03.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sodium butyrate (NaB) has exhibited neuroprotective activity. This study aimed to explore that NaB exerts beneficial effects on chronic unpredictable mild stress (CUMS)-induced depression-like behaviors and its possible mechanisms. The behavioral tests including sucrose preference test (SPT), open field test (OFT), tail suspension test (TST) and forced swimming test (FST) were to evaluate the antidepressant effects of NaB. Then changes of Nissl's body in the hippocampus, brain serotonin (5-HT) concentration, brain-derived neurotrophic factor (BDNF) and tight junctions (TJs) proteins level were assessed to explore the antidepressant mechanisms. Our results showed that CUMS caused significant depression-like behaviors, neuropathological changes, and decreased brain 5-HT concentration, TJs protein levels and BDNF expression in the hippocampus. However, NaB treatment significantly ameliorated behavioral deficits of the CUMS-induced mice, increased 5-HT concentration, increased BDNF expression, and up-regulated Occludin and zonula occludens-1(ZO-1) protein levels in the hippocampus, which demonstrated that NaB could partially restore CUMS-induced blood-brain barrier (BBB) impairments. Besides, the pathologic changes were alleviated. In conclusion, these results demonstrated that NaB significantly improved depression-like behaviors in CUMS-induced mice and its antidepressant actions might be related with, at least in part, the increasing brain 5-HT concentration and BDNF expression and restoring BBB impairments. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：159 / 166

页数：8

共 74 条

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