Microglia and sexual differentiation of the developing brain: A focus on ontogeny and intrinsic factors

被引：72

作者：

Bordt, Evan A. ^{[1
]}

Ceasrine, Alexis M. ^{[2
]}

Bilbo, Staci D. ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp Children, Lurie Ctr Autism, Dept Pediat, Boston, MA 02115 USA

[2] Duke Univ, Dept Psychol & Neurosci, Durham, NC 27708 USA

来源：

GLIA | 2020年 / 68卷 / 06期

关键词：

CENTRAL-NERVOUS-SYSTEM; Y-CHROMOSOME; MATERNAL INHERITANCE; CEREBRAL PERFUSION; GENDER-DIFFERENCES; OXIDATIVE STRESS; ADULT MICROGLIA; YOLK-SAC; CELLS; EXPRESSION;

D O I：

10.1002/glia.23753

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sexual differentiation of the brain during early development likely underlies the strong sex biases prevalent in many neurological conditions. Mounting evidence indicates that microglia, the innate immune cells of the central nervous system, are intricately involved in these sex-specific processes of differentiation. In this review, we synthesize literature demonstrating sex differences in microglial number, morphology, transcriptional state, and functionality throughout spatiotemporal development as well as highlight current literature regarding ontogeny of microglia. Along with vanRyzin et al. in this issue, we explore the idea that differences in microglia imparted by chromosomal or ontogeny-related programming can influence microglial-driven sexual differentiation of the brain, as well as the idea that extrinsic differences in the male and female brain microenvironment may in turn impart sex differences in microglia.

引用

页码：1085 / 1099

页数：15

共 121 条

[1] Sex differences of human cortical blood flow and energy metabolism [J].

Aanerud, Joel ;

Borghammer, Per ;

Rodell, Anders ;

Jonsdottir, Kristjana Y. ;

Gjedde, Albert .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2017, 37 (07) :2433-2440

[2] Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models [J].

Ajami, Bahareh ;

Samusik, Nikolay ;

Wieghofer, Peter ;

Ho, Peggy P. ;

Crotti, Andrea ;

Bjornson, Zach ;

Prinz, Marco ;

Fantl, Wendy J. ;

Nolan, Garry P. ;

Steinman, Lawrence .

NATURE NEUROSCIENCE, 2018, 21 (04) :541-+

[3] Gender-Based Cerebral Perfusion Differences in 46,034 Functional Neuroimaging Scans [J].

Amen, Daniel G. ;

Trujillo, Manuel ;

Keator, David ;

Taylor, Derek V. ;

Willeumier, Kristen ;

Meysami, Somayeh ;

Raji, Cyrus A. .

JOURNAL OF ALZHEIMERS DISEASE, 2017, 60 (02) :605-614

[4] Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex [J].

Arno, Benedetta ;

Grassivaro, Francesca ;

Rossi, Chiara ;

Bergamaschi, Andrea ;

Castiglioni, Valentina ;

Furlan, Roberto ;

Greter, Melanie ;

Favaro, Rebecca ;

Comi, Giancarlo ;

Becher, Burkhard ;

Martino, Gianvito ;

Muzio, Luca .

NATURE COMMUNICATIONS, 2014, 5

[5] Epigenetic regulation of brain region-specific microglia clearance activity [J].

Ayata, Pinar ;

Badimon, Ana ;

Strasburger, Hayley J. ;

Duff, Mary Kaye ;

Montgomery, Sarah E. ;

Loh, Yong-Hwee E. ;

Ebert, Anja ;

Pimenova, Anna A. ;

Ramirez, Brianna R. ;

Chan, Andrew T. ;

Sullivan, Josefa M. ;

Purushothaman, Immanuel ;

Scarpa, Joseph R. ;

Goate, Alison M. ;

Busslinger, Meinrad ;

Shen, Li ;

Losic, Bojan ;

Schaefer, Anne .

NATURE NEUROSCIENCE, 2018, 21 (08) :1049-+

[6] CEREBRAL GLUCOSE METABOLIC RATES IN NORMAL HUMAN FEMALES VERSUS NORMAL MALES [J].

BAXTER, LR ;

MAZZIOTTA, JC ;

PHELPS, ME ;

SELIN, CE ;

GUZE, BH ;

FAIRBANKS, L .

PSYCHIATRY RESEARCH, 1987, 21 (03) :237-245

[7] A deep profiler's guide to cytometry [J].

Bendall, Sean C. ;

Nolan, Garry P. ;

Roederer, Mario ;

Chattopadhyay, Pratip K. .

TRENDS IN IMMUNOLOGY, 2012, 33 (07) :323-332

[8] New tools for studying microglia in the mouse and human CNS [J].

Bennett, Mariko L. ;

Bennett, F. Chris ;

Liddelow, Shane A. ;

Ajami, Bahareh ;

Zamanian, Jennifer L. ;

Fernhoff, Nathaniel B. ;

Mulinyawe, Sara B. ;

Bohlen, Christopher J. ;

Adil, Aykezar ;

Tucker, Andrew ;

Weissman, Irving L. ;

Chang, Edward F. ;

Li, Gordon ;

Grant, Gerald A. ;

Gephart, Melanie G. Hayden ;

Barres, Ben A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (12) :E1738-E1746

[9] Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry [J].

Boettcher, Chotima ;

Schlickeiser, Stephan ;

Sneeboer, Marjolein A. M. ;

Kunkel, Desiree ;

Knop, Anniki ;

Paza, Evdokia ;

Fidzinski, Pawel ;

Kraus, Larissa ;

Snijders, Gijsje J. L. ;

Kahn, Rene S. ;

Schulz, Axel R. ;

Mei, Henrik E. ;

Hol, Elly M. ;

Siegmund, Britta ;

Glauben, Rainer ;

Spruth, Eike J. ;

de Witte, Lot D. ;

Priller, Josef .

NATURE NEUROSCIENCE, 2019, 22 (01) :78-+

[10] Mitochondria, Maternal Inheritance, and Male Aging [J].

Camus, M. Florencia ;

Clancy, David J. ;

Dowling, Damian K. .

CURRENT BIOLOGY, 2012, 22 (18) :1717-1721

← 1 2 3 4 5 6 7 8 9 10 →