An Update on Childhood-Onset Takayasu Arteritis

被引：12

作者：

Aeschlimann, Florence A. ^{[1
]}

Yeung, Rae S. M. ^{[2
,3
,4
]}

Laxer, Ronald M. ^{[2
,5
]}

机构：

[1] Hop Necker Enfants Malad, Pediat Immunol Hematol & Rheumatol Unit, Paris, France

[2] Hosp Sick Children, Dept Pediat, Div Rheumatol, Toronto, ON, Canada

[3] Univ Toronto, Dept Pediat, Toronto, ON, Canada

[4] Univ Toronto, Dept Immunol, Toronto, ON, Canada

[5] Univ Toronto, Dept Med, Toronto, ON, Canada

来源：

FRONTIERS IN PEDIATRICS | 2022年 / 10卷

关键词：

Takayasu Arteritis; large vessel vasculitis; childhood vasculitis; pediatrics; review; TOCILIZUMAB TREATMENT; CLINICAL-COURSE; RENOVASCULAR HYPERTENSION; SUSCEPTIBILITY LOCI; ENDOTHELIAL-CELLS; DISEASE-ACTIVITY; DOUBLE-BLIND; AORTIC-WALL; CASE SERIES; VASCULITIS;

D O I：

10.3389/fped.2022.872313

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Takayasu Arteritis (TAK) is a rare large vessel vasculitis affecting the aorta and its major branches. The heterogeneous and often severe clinical manifestations result from systemic and local inflammation as well as end-organ ischemia. Disease flares are common and contribute to accrued damage over time with significant morbidity and mortality. Newer understanding of the pathogenesis in TAK has paved the way for the use of pathway targeting agents such as tumor necrosis factor (TNF)alpha- or interleuking (IL)-6-inhibitors with improved disease control. Nevertheless, long-term data are lacking, particularly in children; prognosis often remains guarded and the disease burden high. This article aims at providing a comprehensive review of childhood-onset TAK with a focus on recent publications.

引用

页数：14

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