First Report on Cydonia oblonga Miller Anticancer Potential: Differential Anti proliferative Effect against Human Kidney and Colon Cancer Cells

被引：79
作者：
Carvalho, Marcia [1 ,2 ]
Silva, Branca M. [1 ,3 ]
Silva, Renata [2 ]
Valentao, Patricia [3 ]
Andrade, Paula B. [3 ]
Bastos, Maria L. [2 ]
机构：
[1] Univ Fernando Pessoa, Fac Hlth Sci, Res Grp Toxicol & Phytochem, CIBIMED, P-4200150 Oporto, Portugal
[2] Univ Porto, Fac Pharm, Dept Toxicol, P-4050047 Oporto, Portugal
[3] Univ Porto, Fac Pharm, Dept Pharmacognosy, P-4050047 Oporto, Portugal
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2010年 / 58卷 / 06期
关键词：
Cydonia oblonga Miller; quince; phenolic compounds; antiproliferative activity; kidney cancer; colon cancer; STRUCTURE ELUCIDATION; PHENOLIC PROFILE; CHINESE QUINCE; ELLAGIC ACID; ANTIOXIDANT; PREVENTION; POLYPHENOLS; INDUCTION; APOPTOSIS; THERAPY;
D O I：
10.1021/jf903836k
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
The present study reports the phenolic profile and antiproliferative properties of quince (Cydonia oblonga Miller) leaf and fruit (pulp, peel, and seed) against human kidney and colon cancer cells. The phenolic profiles of quince methanolic extracts were determined by high-performance liquid chromatography (HPLC)/diode array detector (DAD). 5-O-Caffeoylquinic acid was always one of the two major phenolic compounds present in all extracts, except for seed. Our results revealed that quince leaf and fruit extracts exhibited distinctive antiproliferative activities. The extracts from quince leaf showed concentration-dependent growth inhibitory activity toward human colon cancer cells (IC50 = 239.7 +/- 43.2 mu g/mL), while no effect was observed in renal adenocarcinoma cells. Concerning the fruit, seed extracts exhibited no effect on colon cancer cell growth, whereas strong antiproliferative efficiency against renal cancer cells was observed for the highest concentration assayed (500 mu g/mL). The anti proliferative activity of pulp and peel extracts was low or absent in the selected range of extract concentrations. This is the first report showing that C. oblonga may be useful as a cancer chemopreventive and/or chemotherapeutic agent.
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收藏
页码：3366 / 3370
页数：5
相关论文
共 39 条
[1]   Molecular targets of dietary agents for prevention and therapy of cancer [J].
Aggarwal, BB ;
Shishodia, S .
BIOCHEMICAL PHARMACOLOGY, 2006, 71 (10) :1397-1421
[2]   Antioxidant and anti proliferative activities of phytochemicals from Quince (Cydonia vulgaris) peels [J].
Alesiani, Daniela ;
Canini, Antonella ;
D'Abrosca, Brigida ;
DellaGreca, Marina ;
Fiorentino, Antonio ;
Mastellone, Claudio ;
Monaco, Pietro ;
Pacifico, Severina .
FOOD CHEMISTRY, 2010, 118 (02) :199-207
[3]   Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2) [J].
Belen Granado-Serrano, Ana ;
Angeles Martin, Maria ;
Bravo, Laura ;
Goya, Luis ;
Ramos, Sonia .
JOURNAL OF NUTRITION, 2006, 136 (11) :2715-2721
[4]   Antiproliferative and antioxidant activities of common vegetables: A comparative study [J].
Boivin, Dominique ;
Lamy, Sylvie ;
Lord-Dufour, Simon ;
Jackson, Jessica ;
Beaulieu, Edith ;
Cote, Martine ;
Moghrabi, Albert ;
Barrette, Stephane ;
Gingras, Denis ;
Beliveau, Richard .
FOOD CHEMISTRY, 2009, 112 (02) :374-380
[5]   Natural polyphenols as proteasome modulators and their role as anti-cancer compounds [J].
Bonfili, Laura ;
Cecarini, Valentina ;
Amici, Manila ;
Cuccioloni, Massimiliano ;
Angeletti, Mauro ;
Keller, Jeffrey N. ;
Eleuteri, Anna M. .
FEBS JOURNAL, 2008, 275 (22) :5512-5526
[6]  
CARMICHAEL J, 1987, CANCER RES, V47, P936
[7]   Evaluation of free radical-scavenging and antihemolytic activities of quince (Cydonia oblonga) leaf: A comparative study with green tea (Camellia sinensis) [J].
Costa, Rossana M. ;
Magalhaes, Ana S. ;
Pereira, Jose A. ;
Andrade, Paula B. ;
Valentao, Patricia ;
Carvalho, Marcia ;
Silva, Branca M. .
FOOD AND CHEMICAL TOXICOLOGY, 2009, 47 (04) :860-865
[8]  
DACUNHA AP, 2005, FARMACOGNOSIA FITOQU
[9]   Antimicrobial activity of tunisian quince (Cydonia oblonga Miller) pulp and peel polyphenolic extracts [J].
Fattouch, Sami ;
Caboni, Pierluigi ;
Coroneo, Valentina ;
Tuberoso, Carlo I. G. ;
Angioni, Alberto ;
Dessi, Sandro ;
Marzouki, Nejib ;
Cabras, Paolo .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (03) :963-969
[10]   Isolation and structure elucidation of antioxidant polyphenols from quince (Cydonia vulgaris) peels [J].
Fiorentino, Antonio ;
D'Abrosca, Brigida ;
Pacifico, Severina ;
Mastellone, Claudio ;
Piscopo, Vincenzo ;
Caputo, Romualdo ;
Monaco, Pietro .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (08) :2660-2667
1234