Biotransformation of jatrophone by Aspergillus niger ATCC 16404

被引：0
作者：
Pertino, Mariano
Schmeda-Hirschmann, Guillermo
Santos, Leonardo S.
Rodriguez, Jaime A.
Theoduloz, Cristina
机构：
[1] Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Talca, Chile
[2] Univ Talca, Inst Quim Recursos Nat, Lab Sintesis Asimetr, Talca, Chile
[3] Univ Talca, Lab Cultivo Celular, Fac Ciencias Salud, Talca, Chile
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2007年 / 62卷 / 02期
关键词：
biotransformation; jatrophone; Aspergillus niger;
D O I：
暂无
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Biotransformation of the diterpene jatrophone (1) by Aspergillus niger ATCC 16404 afforded the new diterpene 9 beta-hydroxyisabellione (2). The compounds were characterized by spectroscopic analysis. The cytotoxicity of the compounds as IC50 values on AGS and lung fibroblasts was 2.4 and 2.8 mu M for compound 1 and 53.1 and 260 mu M for 2, respectively. Microbial transformation of 1 into compound 2 strongly reduced the cytotoxicity and enhanced the selectivity against AGS cells.
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页码：275 / 279
页数：5
相关论文
共 29 条
[1]   Microbial transformation of isosteviol and inhibitory effects on Epstein-Barr virus activation of the transformation products [J].
Akihisa, T ;
Hamasaki, Y ;
Tokuda, H ;
Ukiya, M ;
Kimura, Y ;
Nishino, H .
JOURNAL OF NATURAL PRODUCTS, 2004, 67 (03) :407-410
[2]   EVIDENCE FOR THE MECHANISM OF THE INHIBITORY-ACTION OF JATROPHONE IN THE ISOLATED RAT UTERINE MUSCLE [J].
CALIXTO, JB ;
SANTANA, AEG .
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1990, 21 (01) :117-122
[3]   Stemodane and stemarane diterpenoid hydroxylation by Mucor plumbeus and Whetzelinia sclerotiorum [J].
Chen, ARM ;
Ruddock, PLD ;
Lamm, AS ;
Reynolds, WF ;
Reese, PB .
PHYTOCHEMISTRY, 2005, 66 (16) :1898-1902
[4]   Biotransformation of terpenes from Stemodia maritima by Aspergillus niger ATCC 9142 [J].
Chen, ARM ;
Reese, PB .
PHYTOCHEMISTRY, 2002, 59 (01) :57-62
[5]   STUDY OF THE BINDING OF JATROPHONE TO ESCHERICHIA-COLI S-RIBONUCLEIC ACID [J].
DALAGNI, M ;
DEPETRIS, M ;
MARINIBETTOLO, GB ;
TEMUSSI, PA .
FEBS LETTERS, 1983, 164 (01) :51-56
[6]   Biotransformation of the diperpenoid, isosteviol, by Aspergillus niger, Penicillium chrysogenum and Rhizopus arrhizus [J].
de Oliveira, BH ;
dos Santos, MC ;
Leal, PC .
PHYTOCHEMISTRY, 1999, 51 (06) :737-741
[7]   Jatrophone and 12-O-tetradecanoyl phorbol-13-acetate antagonism of stimulation of natural killer activity and lymphocyte proliferation [J].
deMoraes, VLG ;
Rumjanek, VM ;
Calixto, JB .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 312 (03) :333-339
[8]  
dos Santos AF, 1999, PHYTOTHER RES, V13, P660, DOI 10.1002/(SICI)1099-1573(199912)13:8&lt
[9]  
660::AID-PTR528&gt
[10]  
3.0.CO
123