Altering the Response to Radiation: Sensitizers and Protectors

被引：35

作者：

Citrin, Deborah E.

Mitchell, James B.

机构：

[1] NCI, Radiat Oncol Branch, Bethesda, MD 20892 USA

[2] NCI, Radiat Biol Branch, Bethesda, MD 20892 USA

来源：

SEMINARS IN ONCOLOGY | 2014年 / 41卷 / 06期

基金：

美国国家卫生研究院;

关键词：

IN-VIVO RADIOSENSITIZATION; DNA-REPAIR; MOLECULAR-AGENTS; NORMAL-TISSUES; DAMAGE REPAIR; BREAST-CANCER; RAS ONCOGENES; HELA-CELLS; TUMOR; THERAPY;

D O I：

10.1053/j.seminoncol.2014.09.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A number of agents are used clinically to enhance the efficacy of radiotherapy today, many of which are cytotoxic chemotherapies. Agents that enhance radiation induced tumor cell killing or protect normal tissues from the deleterious effects of ionizing radiation are collectively termed radiation modifiers. A significant effort in radiobiological research is geared towards describing and testing radiation modifiers with the intent of enhancing the therapeutic effects of radiation while minimizing normal tissue toxicity. In this review, we discuss the characteristics of these agents, the testing required to translate these agents into clinical trials, and highlight some challenges in these efforts. Published by Elsevier Inc.

引用

页码：848 / 859

页数：12

共 64 条

[1] Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial [J].